Antibiotic hydrophilic polymer coating

• US 6,436,422 B1
• Filed: 11/23/1998
• Issued: 08/20/2002
• Est. Priority Date: 11/23/1998
• Status: Expired due to Fees

• Current Assignee: Sciessent, LLC
• Original Assignee: AgION Technologies, LLC
• Inventors: Trogolo, Jeffrey A., Barry, John E.
• Primary Examiner(s): CELSA, BENNETT M
• Application Number:
  US09/197,815
• Time in Patent Office: 1,366 Days
• Field of Search: 424/405, 424/404, 424/421, 424/490
• US Class Current: 424/405
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 29/106 Inorganic materials other than carbon
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence

Abstract

The invention relates to an antibiotic coated substrate having an antibiotic coating composition coated thereon. The coating composition is formed of a hydrophilic polymer having antibiotic ceramic particles, preferably antibiotic zeolite, dispersed therein. The antibiotic zeolite may further comprise a discoloration agent. Another embodiment of the invention is an article comprising a substrate on which is coated the antibiotic hydrophilic coating composition. A method for preparing the antibiotic hydrophilic polymer coating on a substrate is also provided.

Claims

1. An antibiotic coating solution comprising a hydrophilic polymer having antibiotic ceramic particles dispersed therein and an organic solvent wherein the hydrophilic polymer is selected from the group consisting of polyhydroxyethyl methacrylate, polyacrylamide, N-vinyl-2-pyrrolidinone, and hydrophilic polyurethane and the antibiotic ceramic particles comprise ion-exchanged antibiotic metal ions.

2. An antibiotic coating solution according to claim 1, wherein the antibiotic ceramic particles are selected from the group consisting of ion-exchanged zeolite, hydroxyapatite, and zirconium phosphate.

3. An antibiotic coating solution according to claim 2, wherein the antibiotic ceramic particles are ion-exchanged zeolite.

4. An antibiotic coating solution according to claim 3, wherein said ion-exhanged zeolite comprises an antibiotic metal ion selected from the group consisting of silver, copper, zinc, mercury, tin, lead, bismyth, bismutin, cadmium, chromium and thallium.

5. An antibiotic coating solution according to claim 1, wherein said ion-exchanged ceramic particles comprise an antibiotic metal ion selected from the group consisting of silver, copper, zinc, mercury, tin, lead, bismyth, bismutin, cadmium, chromium and thallium.

6. An antibiotic coating solution according to claim 1, wherein said polymer further comprises an inorganic discoloration agent.

7. An antibiotic coating solution according to claim 6, wherein said inorganic discoloration agent is ammonium.

8. An antibiotic coating solution according to claim 3, wherein said antibiotic zeolite further comprises ion-exchanged ammonium ions.

9. An antibiotic coating solution according to claim 1, wherein said organic solvent is selected from a group consisting of tetrahydrofuran, dimethylacetamide, methylethylketone, and mixtures thereof.

10. An antibiotic coating solution according to claim 1, wherein said coating solution comprises from about 0.01 to about 50% by weight solids.

11. An antibiotic coating solution according to claim 10, wherein said coating solution comprises from about 0.1 to about 30% by weight solids.

12. An antibiotic coating solution according to claim 11, wherein said coating solution comprises from about 1 to about 20% by weight solids.

13. An antibiotic coating solution according to claim 1, having a content of solids therein, wherein the antibiotic ceramic particles constitute a portion of the solids and the solids of said coating solution comprised from about 0.01 to about 90% by weight of antibiotic zeolite.

14. An antibiotic coating solution according to claim 13, wherein the solids of said coating solution comprise from about 0.05 to about 80% by weight of antibiotic zeolite.

15. An antibiotic coating solution according to claim 14, wherein the solids of said coating solution comprise from about 0.1 to about 70% by weight of antibiotic zeolite.

16. An antibiotic coating solution according to claim 1, having a content of solids therein, wherein the antibiotic ceramic particles constitute a portion of the solids, and the solids of said coating solution comprised from about 10 to about 99.99% by weight of hydrophilic polymer.

17. An antibiotic coating solution according to claim 14, wherein the solids of said coating solution comprise from about 20 to about 99.95% by weight of hydrophilic polymer.

18. An antibiotic coating solution according to claim 17, wherein the solids of said coating solution comprise from about 30 to about 99.9% by weight of hydrophilic polymer.