Device and method for treating ophthalmic diseases
First Claim
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1. A method for delivering a biologically active molecule to the eye comprising:
- implanting a capsule into the anterior chamber, posterior chamber, or vitreous of the eye, the capsule comprising a core containing living cells providing a cellular source of the biologically active molecule and a surrounding biocompatible jacket, the jacket permitting diffusion of the biologically active molecule into the eye, the capsule configured in a shape adapted to implantation in the anterior chamber, posterior chamber, or vitreous of the eye and optionally having a tether that is adapted to secure the capsule in place wherein the dosage of the biologically active molecule that diffuses into the eye is between 50 pg and 1000 ng per eye per patient per day.
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Abstract
The invention provides a method for delivering biologically active molecules to the eye by implanting biocompatible capsules containing a cellular source of the biologically active molecule. Also provided is a method of treating ophthalmic diseases using biocompatible capsules.
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Citations
7 Claims
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1. A method for delivering a biologically active molecule to the eye comprising:
implanting a capsule into the anterior chamber, posterior chamber, or vitreous of the eye, the capsule comprising a core containing living cells providing a cellular source of the biologically active molecule and a surrounding biocompatible jacket, the jacket permitting diffusion of the biologically active molecule into the eye, the capsule configured in a shape adapted to implantation in the anterior chamber, posterior chamber, or vitreous of the eye and optionally having a tether that is adapted to secure the capsule in place wherein the dosage of the biologically active molecule that diffuses into the eye is between 50 pg and 1000 ng per eye per patient per day. - View Dependent Claims (2, 3, 4)
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5. A method for treating ophthalmic disorders in a patient suffering therefrom, comprising implanting into one or both eyes of the patient, a biocompatible capsule, the capsule comprising:
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(a) a core comprising a cellular source of a biologically active molecule, and (b) a jacket surrounding said core, the jacket comprising a biocompatible material that permits diffusion of the biologically active molecule to the eye in a therapeutically effective amount, wherein the dosage of the biologically active molecule that diffuses into the eye is between 50 pg and 1000 ng per eye per patient per day and wherein the ophthalmic disorder is selected from the group consisting of uveitis, retinitis pigmentosa, glaucoma, age-related macular degeneration, and diabetic retinopathy. - View Dependent Claims (6, 7)
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Specification