Method of producing a reactive coating by after-glow plasma polymerization

• US 6,436,481 B1
• Filed: 06/22/1999
• Issued: 08/20/2002
• Est. Priority Date: 12/23/1996
• Status: Expired due to Fees

• Current Assignee: Novartis Ag
• Original Assignee: Novartis Ag
• Inventors: Lohmann, Dieter, Chabrecek, Peter
• Primary Examiner(s): Thibodeau, Paul
• Assistant Examiner(s): Jackson, Monique R.
• Application Number:
  US09/331,516
• Time in Patent Office: 1,155 Days
• Field of Search: 523/105-108, 525/937, 427/446-449, 427/488, 427/491, 428/220, 428/332, 428/333, 428/336, 428/338, 428/341, 428/410, 428/411.1, 428/413, 428/423.1, 428/500, 428/524, 428/923, 428/926, 351/160.R, 351/160.H
• US Class Current: 427/488
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: B01D 2323/30 Cross-linking
• CPC Class Codes: B01D 67/00933 by addition of a layer chemically bonded to the membrane
• CPC Class Codes: B01D 69/127 using electrical discharge or plasma-polymerisation
• CPC Class Codes: C08J 7/123 Treatment by wave energy or particle radiation C08J7/18 takes precedence
• CPC Class Codes: G02B 1/043 Contact lenses
• CPC Class Codes: Y10T 428/26 Web or sheet containing structurally defined element or component, the element or component having a specified physical dimension

Abstract

The present invention describes coated articles and methods for preparing such articles, wherein the primary coating comprises a plasma-induced polymer carrying reactive groups. The invention further relates to the reaction of said primary coatings carrying reactive groups with monomeric, oligomeric or macromolecular compounds of synthetic, semisynthetic or biological origin to provide hybrid-type coated articles (secondary coatings).

Claims

1. A method of preparing an article comprising a substrate with a polymer coating carrying reactive groups on its surface, wherein said polymeric coating comprises repeating units derived from a polymerizable unsaturated compound carrying a reactive group selected from the group consisting of isocyanato, isothiocyanato, glycidyl, anhydride, azlactone and lactone groups, wherein in said coating the concentration of said reactive groups is, based on spin label determination by ESR spectroscopy, in a range of 0.2-20·

10−

9 Mol spin/cm2, wherein said coating is obtained by carrying out an after-glow plasma-induced polymerization of a polymerizable unsaturated compound carrying a reactive group selected from the group consisting of isocyanato, isothiocyanato, glycidyl, anhydride, azlactone and lactone groups on a substrate wherein the substrate is positioned at a distance of 4 to 40 cm and an inlet for said polymerizable unsaturated compound at a distance of 3 to 35 cm downstream outside of a plasma zone.

2. A method according to claim 1, wherein the plasma-induced polymerization is induced by a direct current (DC), a radio frequency (RF) or a microwave (MV) plasma.

3. A method according to claim 2, wherein the plasma-induced polymerization is induced by a RF plasma with inductive coupling.

4. A method according to claim 2, wherein the radio frequency is 13.56 or 27.12 MHz.

5. A method according to claim 1, wherein the plasma-induced polymerization is induced by a pulsed plasma.

6. A method according to claim 1, wherein the substrate is positioned at a distance of 8 to 30 cm downstream from the plasma zone.

7. A method according to claim 1 wherein the inlet is positioned at a distance of 6 to 25 cm downstream from the plasma zone.

8. A method according to claim 1, wherein the article is an ophthalmic device for vision correction, wherein the plasma-induced polymerization is carried out in the presence of the substrate that carries a removable patterned screen as a mask for the generation of imaged surfaces.