Method and apparatus employing a scaling exponent for selectively defibrillating a patient

• US 6,438,419 B1
• Filed: 09/28/2000
• Issued: 08/20/2002
• Est. Priority Date: 09/28/2000
• Status: Expired due to Fees

• Current Assignee: University of Pittsburgh of The Commonwealth System of Higher Education
• Original Assignee: University Of Pittsburgh (University of Pittsburgh of The Commonwealth System of Higher Education)
• Inventors: Sherman, Lawrence D., Callaway, Clifton W.
• Primary Examiner(s): Schaetzle, Kennedy
• Assistant Examiner(s): DROESCH, KRISTEN L
• Application Number:
  US09/672,647
• Time in Patent Office: 691 Days
• Field of Search: 600/508, 600/509, 600/515, 600/518, 607/4-8, 607/142
• US Class Current: 607/5
• CPC Class Codes: A61N 1/3925 Monitoring; Protecting

Abstract

A defibrillator, which selectively delivers a defibrillation pulse to a patient, includes electrodes adapted for placement on the patient, a monitoring circuit for providing an electrocardiogram (ECG) of the patient, and a defibrillation pulse generator having an energy store for delivering a defibrillation pulse. A switch in electrical communication with the ECG monitoring circuit and the defibrillation pulse generator selectively electrically connects the monitoring circuit and the defibrillation pulse generator to the electrodes. A microprocessor is in electrical communication with the monitoring circuit, the defibrillation pulse generator, and the switch. The microprocessor causes the switch to electrically connect the monitoring circuit to the electrodes in order to provide the ECG of the patient. The microprocessor also determines a scaling exponent for the patient from the ECG thereof. The microprocessor further compares the scaling exponent to a predetermined value and selectively causes the switch to electrically connect the defibrillation pulse generator to the electrodes in order that the energy store delivers the defibrillation pulse to the patient.

Claims

1. A defibrillator for selectively delivering a defibrillation pulse to a patient, said defibrillator comprising:

electrodes adapted for placement on the patient;

a monitoring circuit for providing an electrocardiogram (ECG) of the patient;

a defibrillation pulse generator including an energy store for delivering a defibrillation pulse;

a switch in electrical communication with the monitoring circuit and the defibrillation pulse generator for selectively electrically connecting the monitoring circuit and the defibrillation pulse generator to the electrodes; and

a control system in electrical communication with the monitoring circuit, the defibrillation pulse generator, and the switch,

said control system comprising means for;

(i) causing the switch to electrically connect the monitoring circuit to the electrodes in order to provide the ECG of the patient,

(ii) determining a scaling exponent for the patient from the ECG thereof , and

(iii) comparing the scaling exponent to a predetermined value and selectively causing the switch to electrically connect the defibrillation pulse generator to the electrodes in order that the energy store delivers the defibrillation pulse to the patient.

2. The defibrillator of claim 1, wherein said control system includes a display operatively associated therewith for displaying the scaling exponent.

3. The defibrillator of claim 1, wherein said control system includes a non-volatile memory for storing the predetermined value.

4. The defibrillator of claim 1, wherein said control system includes an input for entering the predetermined value.

5. A defibrillator for selectively delivering a defibrillation pulse to a patient, said defibrillator comprising:

electrodes adapted for placement on the patient;

a monitoring circuit for providing an electrocardiogram (ECG) of the patient;

a defibrillation pulse generator including an energy store for delivering a defibrillation pulse;

a switch in electrical communication with the monitoring circuit and the defibrillation pulse generator for selectively electrically connecting the monitoring circuit and the defibrillation pulse generator to the electrodes; and

a control system in electrical communication with the monitoring circuit, the defibrillation pulse generator, and the switch for;

(i) causing the switch to electrically connect the monitoring circuit to the electrodes in order to provide the ECG of the patient,

(ii) determining a scaling exponent for the patient from the ECG thereof, and

(iii) comparing the scaling exponent to a predetermined value and selectively causing the switch to electrically connect the defibrillation pulse generator to the electrodes in order that the energy store delivers the defibrillation pulse to the patient,

wherein said control system includes means for adjusting the predetermined value.

6. A defibrillator for selectively delivering a defibrillation pulse to a patient, said defibrillator comprising:

electrodes adapted for placement on the patient;

a monitoring circuit for providing an electrocardiogram (ECG) of the patient;

a defibrillation pulse generator including an energy store for delivering a defibrillation pulse;

a switch in electrical communication with the monitoring circuit and the defibrillation pulse generator for selectively electrically connecting the monitoring circuit and the defibrillation pulse generator to the electrodes; and

a control system in electrical communication with the monitoring circuit, the defibrillation pulse generator, and the switch,

said control system comprising means for;

(i) causing the switch to electrically connect the monitoring circuit to the electrodes in order to take the ECG of the patient,

(ii) determining a scaling exponent for the patient from the ECG thereof,

(iii) displaying the scaling exponent, and

(iv) receiving an input responsive to said displaying and selectively causing the switch to electrically connect the defibrillation pulse generator to the electrodes in order that the energy store delivers the defibrillation pulse to the patient.

7. A method of selectively delivering a defibrillation pulse to a patient comprising the steps of:

placing electrodes on the patient;

taking an electrocardiogram (ECG) of the patient;

determining a scaling exponent for the patient from the ECG thereof ;

comparing the scaling exponent to a predetermined value; and

selectively delivering a defibrillation pulse through the electrodes to the patient based upon said comparing step.

8. The method of claim 7 further comprising:

employing about 1.3 as said predetermined value;

comparing the scaling exponent to said predetermined value of about 1.3; and

selectively delivering the defibrillation pulse when the scaling exponent is less than said predetermined value of about 1.3.

9. The method of claim 7 further comprising:

delivering another defibrillation pulse after said step of selectively delivering a defibrillation pulse.

10. The method of claim 7 further comprising:

manually overriding said steps of taking an ECG, determining a scaling exponent, comparing the scaling exponent, and selectively delivering a defibrillation pulse; and

manually initiating delivery of a defibrillation pulse.

11. The method of claim 7 further comprising:

employing a human being as said patient.

12. The method of claim 7 further comprising:

employing a member of the animal kingdom as said patient.

13. The method of claim 7 further comprising:

employing said steps of taking an ECG, determining a scaling exponent, comparing the scaling exponent, and selectively delivering a defibrillation pulse in real time.

14. The method of claim 7 further comprising:

displaying the scaling exponent.

15. The method of claim 7 further comprising:

selectively delivering the defibrillation pulse to the patient when the scaling exponent is less than the predetermined value.

16. The method of claim 15 further comprising:

employing about 1.3 as said predetermined value.

17. The method of claim 7 further comprising:

selectively displaying a suggested alternative therapy when the scaling exponent is greater than the predetermined value.

18. The method of claim 17 further comprising:

employing about 1.3 as said predetermined value.

19. The method of claim 7 further comprising:

selectively displaying a suggested alternative therapy for the patient when the scaling exponent is greater than said predetermined value.

20. The method of claim 19 further comprising:

employing reperfusion as said suggested alternative therapy.

21. The method of claim 19 further comprising:

employing as said suggested alternative therapy;

reoxygenating a fibrillating heart of the patient; and

employing defibrillation after said reoxygenating step.

22. The method of claim 19 further comprising:

employing as said suggested alternative therapy;

employing artificial perfusion; and

employing defibrillation after said employing artificial perfusion step.

23. The method of claim 19 further comprising:

employing a period of cardiopulmonary resuscitation (CPR) as said suggested alternative therapy.

24. The method of claim 23 further comprising:

employing defibrillation after said period of CPR.

25. The method of claim 19 further comprising:

employing at least one of cardiopulmonary resuscitation (CPR) and ventilating the patient as said suggested alternative therapy.

26. The method of claim 25 further comprising:

employing defibrillation after said at least one of said CPR and said ventilating the patient.

27. The method of claim 7 further comprising:

expressing said ECG as series of a plurality of voltage measurements.

28. The method of claim 27 further comprising:

varying a lag from;

(a) a difference between adjacent pairs of said voltage measurements to (b) a difference between each N-th pair of said voltage measurements.

29. The method of claim 28 further comprising:

employing k as said lag;

employing i as an index of said voltage measurements;

employing X(i) as one of said voltage measurements;

employing X(i+k) as another one of said voltage measurements;

calculating a sum of absolute potential differences between each i-th measurement of said ECG, X(i), and each (i+k)-th measurement of said ECG, X(i+k).

30. The method of claim 29 further comprising:

employing M as a count of said voltage measurements;

normalizing said sum for each value of said lag, k, by a factor, [M/k(M−

k)]; and

defining a function, L(k), as said sum;

$L<br><br>\left(k\right)=M/\left(k<br><br>\left(M-k\right)\right)\times <br><br>\underset{i=1}{\overset{M-k}{\sum <br><br>}}<br><br>\text{\hspace{1em}<br><br>}<br><br><br><br>X<br><br>\left(i\right)-X<br><br>\left(i+k\right)<br><br>.$

31. The method of claim 28 further comprising:

employing d as the scaling exponent; and

fitting values of said function, L(k), to an exponential function in order to describe a scaling relationship between said function, L(k), and said lag, k;

32. The method of claim 31 further comprising:

employing said function, L(k), with a plateau in a region centered between about k=5 and about k=20;

defining a plurality of regions, each of which has about five values of said function, L(k);

calculating a plurality of slopes of said function, L(k), for each of said regions centered between about k=5 and about k=20; and

identifying an inflection point of said function, L(k), from a maximum one of said slopes.

33. The method of claim 32 further comprising:

employing a plurality of points centered around said inflection point; and

fitting a slope of a least-squares line to a log-log plot of said function, L(k).

34. The method of claim 33 further comprising:

calculating the scaling exponent, d, from said slope of a least-squares line.

35. The method of claim 30 further comprising:

employing about 2048 as said count, M, of said voltage measurements.

36. The method of claim 35 further comprising:

measuring said voltage measurements at a rate of about 400 measurements per second.

37. A method of diagnosing and treating a patient comprising the steps of:

placing electrodes on the patient;

taking an electrocardiogram (ECG) of the patient;

determining a scaling exponent for the patient from the ECG thereof;

displaying the scaling exponent;

receiving an input responsive to said step of displaying the scaling exponent; and

selectively defibrillating the patient responsive to said receiving step.

38. The method of claim 37 further comprising:

employing an input from an operator as said input responsive to said step of displaying the scaling exponent.