Pressure support ventilation control system and method

• US 6,439,229 B1
• Filed: 08/08/2000
• Issued: 08/27/2002
• Est. Priority Date: 08/08/2000
• Status: Expired due to Term

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Newport Medical Instruments Incorporated (Medtronic Plc)
• Inventors: Yamada, Yoshitsugu, Amato, Marcelo B. P., Nguyen, Bich N., Du, Hong-Lin
• Primary Examiner(s): Lewis, Aaron J.
• Application Number:
  US09/634,513
• Time in Patent Office: 749 Days
• Field of Search: 128/204.18, 128/204.21, 128/204.23, 128/204.26
• US Class Current: 128/204.23
• CPC Class Codes: A61M 16/026 specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2016/0042 in the expiratory circuit
• CPC Class Codes: A61M 2205/3344 Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 2230/42 Rate

Abstract

A system and method of controlling the termination of the inhalation phase in a pressure support ventilation system is disclosed, in which an expiratory trigger sensitivity, or ratio of inspiratory flow rate to peak inspiratory flow rate at which the inspiration phase is terminated, is varied in proportion to variations in a calculated respiratory time constant. The system includes sensors for monitoring pressure and flow of gas during each breath, and, based on the sensor outputs, calculates the respiratory time constant for one breath or a series of breaths. The expiratory trigger sensitivity is automatically increased with increasing patient respiratory time constant, providing a closed loop control of expiratory trigger sensitivity. The expiratory trigger sensitivity may also be varied in response to changes in supra-plateau pressure.

Claims

1. A pressure support ventilation system, comprising:

a ventilator unit having an input for connection to a source of breathing gases, an inspiration line for connection to a patient, a gas delivery unit for controlling gas delivery from the source to the inspiration line, an expiratory line for exhausting gases from the patient, and an expiratory unit for controlling removal of gases during expiration;

at least one flow sensor for sensing the level of gas flow in the system;

a pressure sensor for sensing pressure in the system; and

a control unit connected to the gas delivery unit, expiratory unit, and the flow and pressure sensors for controlling the gas delivery and expiratory units to provide an inspiration phase in which gases are supplied to the patient through the gas delivery unit and an expiratory phase in which gases are removed from the patient;

the control unit calculating, for each breath, a patient respiratory time constant based on the outputs of the flow and pressure sensors, and including an expiratory trigger sensitivity controller for varying an expiratory trigger sensitivity in response to variations in the calculated patient respiratory time constant, such that the expiratory trigger sensitivity at which the ventilator unit switches from gas delivery to gas removal is increased with increase in the patient respiratory time constant.

2. The system as claimed in claim 1, wherein the expiratory trigger sensitivity controller includes a monitor for monitoring supra-plateau pressure at the end of each inspiration phase and for varying the expiratory trigger sensitivity in response to variations in the supra-plateau pressure, whereby the expiratory trigger sensitivity is also increased with increase in the supra-plateau pressure.

3. The system as claimed in claim 1, wherein the expiratory trigger sensitivity controller comprises a first selector for selecting a predetermined range of expiratory trigger sensitivities based on the calculated patient respiratory time constant, and a second selector for selecting a specific expiratory trigger sensitivity within the range based on the difference between a set target pressure and the actual pressure measured by the pressure sensor at the end of inspiration.

4. The system as claimed in claim 1, wherein the control unit calculates a respiratory time constant for a plurality of successive breaths, and calculates a running average time constant of the previously calculated time constants, and the expiratory trigger sensitivity controller uses the running average time constant to adjust the expiratory trigger sensitivity for the subsequent breath.

5. The system as claimed in claim 2, wherein the control unit increments the expiratory trigger sensitivity by a predetermined percentage in response to variations in the supra-plateau pressure above and below a predetermined target supra-plateau pressure.

6. The system as claimed in claim 5, wherein the predetermined percentage is 5%.

7. The system as claimed in claim 1, wherein there are a plurality of different, increasing expiratory trigger sensitivity ranges for calculated respiratory time constants within a corresponding number of different ranges.

8. A method of controlling the termination of the inhalation phase in a pressure support ventilation system, comprising the steps of:

supplying gases to a patient in a ventilator inspiration phase based on a predetermined target pressure level;

initially selecting a default expiratory trigger sensitivity at which the inspiration phase is terminated and the ventilator switches to expiration;

detecting the pressure and flow of gas during each breath, and calculating a patient respiratory time constant for that breath; and

adjusting the expiratory trigger sensitivity based on the calculated respiratory time constant, such that expiratory trigger sensitivity is increased with increasing patient respiratory time constant.

9. The method as claimed in claim 8, wherein the expiratory trigger sensitivity is adjusted based on a calculated respiratory time constant for one preceding breath.

10. The method as claimed in claim 8, wherein the expiratory trigger sensitivity is adjusted based on the average of a series of calculated respiratory time constants for at least two preceding breaths.

11. The method as claimed in claim 8, including the step of measuring a supra-plateau pressure for each breath, and further adjusting the expiratory trigger sensitivity based on the measured supra-plateau pressure such that expiratory trigger sensitivity is increased with increasing supra-plateau pressure.

12. The method as claimed in claim 8, wherein the step of adjusting the expiratory trigger sensitivity comprises selecting a range of expiratory trigger sensitivities based on the calculated respiratory time constant, and selecting an expiratory trigger sensitivity within the range based on another predetermined criterion.

13. The method as claimed in claim 12, wherein a supra-plateau pressure is measured for each breath, and the selection of an expiratory trigger sensitivity within the selected range is based on the measured supra-plateau pressure.

14. The method as claimed in claim 8, including the step of storing a table comprising a series of different ranges of expiratory trigger sensitivities, each range in the table being associated with a predetermined range of respiratory time constants, and the step of adjusting the expiratory trigger sensitivity comprise looking up the ranges in the table and selecting the range associated with the calculated respiratory time constant.

15. The method as claimed in claim 8, wherein the expiratory trigger sensitivity is adjustable within a range from 10% to 55% dependent on the calculated respiratory time constant.