Multilayer and multifunction vascular graft
First Claim
1. A vascular graft having a lumen passing therethrough, said graft comprising:
- a tubular wall structure including;
a first non-thrombogenic layer formed of a first material and forming the lumen, an interior surface of said first layer being treated with a non-thrombogenic agent, said first layer having a thickness less than 100 μ
m, and a second thrombogenic layer outside said first layer and formed of a second material, an exterior surface of said second layer being treated with a thrombogenic agent, said second layer having a thickness less than 100 μ
m.
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Accused Products
Abstract
A multi-zone, multifinctional graft with two or more zones that have different chemical and biological characteristics is provided. The vascular conduit that has of an inner zone that is permanently non-thrombogenic and anti-proliferative, and one or more outer zones that allow for beneficial tissue in-growth and sealing of the graft to prevent leakage. The small diameter vascular conduits of the present invention containing these different zones may be fabricated from woven or knitted Dacron, extruded porous PTFE, from polyurethane polymer, or other similar materials, and the structure of these conduits so modified as to provide these different zones. One embodiment contains an inner non-thrombogenic layer and an outer thrombogenic layer, optionally containing a growth agent. A second embodiment contains a third intermediate layer having a growth agent impregnated therein.
82 Citations
36 Claims
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1. A vascular graft having a lumen passing therethrough, said graft comprising:
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a tubular wall structure including;
a first non-thrombogenic layer formed of a first material and forming the lumen, an interior surface of said first layer being treated with a non-thrombogenic agent, said first layer having a thickness less than 100 μ
m, anda second thrombogenic layer outside said first layer and formed of a second material, an exterior surface of said second layer being treated with a thrombogenic agent, said second layer having a thickness less than 100 μ
m.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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10. A vascular graft having a lumen passing therethrough, said graft comprising:
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a tubular wall structure including;
a first non-thrombogenic layer formed of a first material and forming the lumen, an interior surface of said first layer being formed by chemically binding a non-thrombogenic agent to said first material, thereby permanently forming said first non-thrombogenic first layer, said non-thrombogenic agent having a concentration of at least 0.5 IU/cm2 as measured by an ATIII response test, a second thrombogenic layer outside said first layer and formed of a second material, an exterior surface of said second layer being treated with a thrombogenic agent. - View Dependent Claims (11, 12)
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24. A vascular graft having a lumen passing therethrough, said graft comprising:
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a first non-thrombogenic layer forming the lumen, said first non-thrombogenic layer having a thickness less than 100 μ
m,a second growth layer outside said first layer, said second layer having a thickness in the range of 100 μ
m to 500 μ
m, anda third thrombogenic layer outside both said first and said second layer, said third layer having a thickness less than 100 μ
m.- View Dependent Claims (25, 26, 30, 31, 32, 33)
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27. A vascular graft having a lumen passing therethrough, said graft comprising:
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a first non-thrombogenic layer forming the lumen, said first non-thrombogenic layer formed by chemically binding a non-thrombogenic agent to a base material, thereby permanently forming said first non thrombogenic layer, and wherein said non-thrombogenic agent has a concentration of at least 0.5 IU/cm2 as measured by an ATIII response test, a second growth layer outside said first layer, and a third thrombogenic layer outside both said first and said second layer. - View Dependent Claims (28, 29)
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34. A vascular graft, comprising:
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a tubular body having a first end, a second end, a wall, an interior surface, an exterior surface and a lumen passing therethrough, said tubular body formed of a biocompatible plastic, said wall of said tubular body treated such that a first inner layer and a second outer layer are formed, said first layer formed of a non-thrombogenic agent chemically bound to said biocompatible plastic on said interior surface of said tubular body, thereby inhibiting the proliferation of undesirable cells within said vascular graft, said first layer having a thickness of less than 25 μ
m,said second layer formed of a thrombogenic material chemically bound to said biocompatible plastic on said exterior surface of said tubular, thereby promoting the infiltration of desirable cells into said second layer, said second layer having a thickness of less than 25 μ
m.- View Dependent Claims (35, 36)
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Specification