Phosphono-carboxylate compounds for treating amyloidosis
First Claim
Patent Images
1. A method for preparing a compound represented by the formula:
-
in which R is alkyl or aryl, and R′
is hydrogen, alkyl, or aryl;
the method comprising;
reacting an ester of a carbonylphosphono diacid halide with a disilylether of a vicinal diol, under conditions such that a compound of said formula is prepared.
2 Assignments
0 Petitions
Accused Products
Abstract
Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, a congener thereof, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.
-
Citations
20 Claims
-
1. A method for preparing a compound represented by the formula:
-
in which R is alkyl or aryl, and R′
is hydrogen, alkyl, or aryl;
the method comprising;reacting an ester of a carbonylphosphono diacid halide with a disilylether of a vicinal diol, under conditions such that a compound of said formula is prepared. - View Dependent Claims (3, 11, 13, 14)
-
-
2. A compound represented by the formula:
-
wherein G is hydrogen or one of more substituents on the aryl ring and the L is a substituted alkyl group. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 20)
-
-
12. A method of synthesizing a compound represented by the formula
wherein G is hydrogen or one or more substituents on the aryl ring and the L is a hydroxy substituted alkyl group; the method comprising reacting an ester of a carbonylphosphono diacid halide with a disilylether of a vicinal diol, under conditions such that the compound of said formula is prepared. - View Dependent Claims (15, 16, 17, 18, 19)
Specification