Antitumor compositions containing taxane derivatives

• US 6,441,026 B1
• Filed: 03/21/2001
• Issued: 08/27/2002
• Est. Priority Date: 11/08/1993
• Status: Expired due to Fees

• Current Assignee: Aventis Pharma SA (Sanofi )
• Original Assignee: Aventis Pharma SA (Sanofi )
• Inventors: Bissery, Marie-Christine
• Primary Examiner(s): OWENS, AMELIA A
• Application Number:
  US09/813,018
• Publication Number:
  US 20020031505A1
• Time in Patent Office: 524 Days
• Field of Search: 514/184, 514/316, 514/410, 514/449, 514/459
• US Class Current: 514/449
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/4745 condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines yohimbine derivatives, vinblastine A61K31/475; ergoline derivatives A61K31/48
• CPC Class Codes: A61K 33/24 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 33/243 Platinum; Compounds thereof
• CPC Class Codes: A61K 38/14 Peptides containing saccharide radicals; Derivatives thereof , e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A pharmaceutical composition comprised of acetocyclopropyl taxotere or a derivatve thereof, and at least one of an alkylating agent, an antimetabolite, a spindle poison, an epidophyllotoxin, an antibiotic, an enzyme, a topoisomerase inhibitor, a platinum coordination complex, a biological response modifier or a growth factor inhibitor is described.

Claims

1. A pharmaceutical composition comprised of the compound of formula 1:

or a derivatve thereof, and at least one of an alkylating agent, an antimetabolite, a spindle poison, an epidophyllotoxin, an antibiotic, an enzyme, a topoisomerase inhibitor, a platinum coordination complex, a biological response modifier or a growth factor inhibitor.

2. The pharmaceutical composition according to claim 1 wherein the antibiotic agent is chosen from daunorubicin, doxorubicin, bleomycin and mitomycin.

3. The pharmaceutical composition according to claim 1 wherein the spindle poison is chosen from vinca alkaloids, their synthetic or semi-synthetic analogues, estramustine or navelbine.

4. The pharmaceutical composition according to claim 1 wherein the topoisomerase inhibitor is chosen from camptothecin and its derivatives including CPT-11, topotecan and pyridobenzoindole derivatives.

5. The pharmaceutical composition according to claim 1 wherein the platinum coordinating complex is chosen from cisplatin and carboplatin.

6. The pharmaceutical composition according to anyone of claims 2 to 5, further comprising growth factors of the haematopoietic type.

7. A method of administering the constituents of the composition as claimed in any one of claims 2 to 5, wherein said administration is separate and simultaneous.

8. A method of administering the constituents of the composition as claimed in any one of claims 2 to 5, wherein said administration is separate and sequential.

9. A method of administering the constituents of the composition as claimed in any one of claims 2 to 5, wherein said administration is separate and spaced out over time.

10. A pharmaceutical composition having therapeutic synergy in the treatment of neoplastic disease comprising a compound of the formula:

and doxorubicin.

14. The pharmaceutical composition of any one of claims 10 to 13 wherein the constituents of the composition are administered simultaneously.

15. The pharmaceutical composition of any one of claims 10 to 13 wherein the constituents of the composition are administered separately and simultaneously.

16. The pharmaceutical composition of any one of claims 10 to 13 wherein the constituents of the composition are administered separately and semi-simultaneously.

17. The pharmaceutical composition of any one of claims 10 to 13 wherein the constituents of the composition are administered separately and sequentially.

18. The pharmaceutical composition of claim 10 or claim 11 wherein the neoplastic disease is breast cancer.

11. A pharmaceutical composition having therapeutic synergy in the treatment of neoplastic disease comprising a compound of the formula:

and navelbine.

12. A pharmaceutical composition having therapeutic synergy in the treatment of neoplastic disease comprising a compound of the formula:

and cisplatin.

19. The pharmaceutical composition of claim 12 or claim 13 wherein the neoplastic disease is colon cancer.

13. A pharmaceutical composition having therapeutic synergy in the treatment of neoplastic disease comprising a compound of the formula:

and CPT 11.