Biological materials

• US 6,441,073 B1
• Filed: 04/17/2001
• Issued: 08/27/2002
• Est. Priority Date: 08/17/1999
• Status: Expired due to Term

• Current Assignee: National Institute for Materials Science, Kawasumi Laboratories Incorporated (Sumitomo Bakelite Company Limited), Taki Chemical Co., Ltd.
• Original Assignee: National Institute for Materials Science, Taki Chemical Co., Ltd.
• Inventors: Ichikawa, Shunji, Tanaka, Shigeo, Shirahama, Noriaki, Takakuda, Kazuo, Koyama, Yoshihisa, Miyamoto, Kimihiro, Yokoyama, Etsuro, Suwa, Shuji, Shono, Soichi, Itoh, Takatoshi, Okada, Takao, Tanaka, Junzo, Kikuchi, Masanori, Imamura, Yukari
• Primary Examiner(s): Yoon, Tae H.
• Application Number:
  US09/807,707
• Time in Patent Office: 497 Days
• Field of Search: 524/414, 523/113, 523/115, 424/426, 528/302
• US Class Current: 524/414
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/127 containing fillers of phosphorus-containing inorganic materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61L 31/18 Materials at least partially X-ray or laser opaque
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

The followings are disclosed herein:

a biomaterial comprising calcium phosphate and a copolymer of lactic acid, glycolic acid and ε-caprolactone;

a biomaterial for the induction of osteoanagenesis, characterized in that a periosteum is attached to the biomaterial comprising calcium phosphate and a copolymer of lactic acid, glycolic acid and ε-caprolactone; and a biomaterial for the prevention of adhesion comprising calcium phosphate and a copolymer of lactic acid, glycolic acid and ε-caprolactone where the molar ratio of lactic acid, glycolic acid and ε-caprolactone is within a range of 5-90:3-75:5-40.

Claims

1. A biomaterial comprising calcium phosphate and a copolymer of lactic acid, glycolic acid and ε

-caprolactone, wherein the ε

-caprolactone content in the copolymer is within a range of about 1 to abut 45 molar % and the glycolic acid content in the copolymer is within a range of about 5 to about 70 molar %.

2. The biomaterial according to claim 1, which is a biomaterial for the induction of osteoanagenesis or a biomaterial for the prevention of adhesion.

8. The biomaterial according to claim 1, wherein a ratio of calcium phosphate to the copolymer in terms of weight is 1:

0.1˜

2.0.

9. The biomaterial according to claim 1, which is manufactured by heating and kneading calcium phosphate with the copolymer.

10. The biomaterial according to claim 9, wherein the heating/kneading temperature is 50-250°

C.

11. The biomaterial according to claim 1, wherein the number-average molecular weight of the copolymer is 30,000-200,000.

12. The biomaterial according to claim 1, wherein calcium phosphate is tricalcium phosphate.

13. The biomaterial according to claim 12, wherein tricalcium phosphate has a particle size of 0.1 to 200 μ

m.

14. The biomaterial according to claim 12, wherein tricalcium phosphate is sintered at 650-1500°

C.

3. A biomaterial for the induction of osteoanagenesis, characterized in that a periosteum is attached to the biomaterial comprising calcium phosphate and a copolymer of lactic acid, glycolic acid and ε

-caprolactone.

4. The biomaterial for the induction of osteoanagenesis according to claim 3, characterized in that a periosteum is attached by means of a suture and an adhesion to the biomaterial.

5. The biomaterial for the induction of osteoanagenesis according to claim 3, whose rigidity is 200-20000 MPa at 4-40°

C.

6. The biomaterial for the induction of osteoanagenesis according to claim 3, characterized in that the copolymer has a molar ratio of lactic acid, glycolic acid and ε

-caprolactone within a range of 5-90;

3-75;

5-40 in the biomaterial.

7. A biomaterial for the prevention of adhesion comprising calcium phosphate and a copolymer of lactic acid, glycolic acid and ε

-caprolactone where the molar ratio of lactic acid, glycolic acid and ε

-caprolactone is within a range of 5-90;

3-75;

5-40.