Epothilone analogs
First Claim
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1. An epothilone analog represented by the following structure:
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Abstract
Epothilone A, epothilone B, analogs of epothilone and libraries of epothilone analogs are synthesized. Epothilone A and B are known anticancer agents that derive their anticancer activity by the prevention of mitosis through the induction and stabilization of microtubulin assembly. The analogs of epothilone are novel. Several of the anlogs are demonstrated to have a superior cytotoxic activities as compared to epothilone A or epothilone B as demonstrated by their enhanced ability to induce the polymerization and stabilization of microtubules.
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Citations
1 Claim
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1. An epothilone analog represented by the following structure:
Specification
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Current AssigneeThe Scripps Research Institute
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Original AssigneeThe Scripps Research Institute
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InventorsSarabia, Francisco, Yang, Zhen, Roschangar, Frank, Pastor, Joaquin, Vourloumis, Dionisios, He, Yun, Ninkovic, Sacha, Winssinger, Nicolas, Nicolaou, Kyriacos C., Vallberg, Hans, Finlay, M. Ray, King, N. Paul
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Primary Examiner(s)STOCKTON, LAURA LYNNE
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Application NumberUS08/923,869Time in Patent Office1,818 DaysField of Search549/562, 548/204, 548/236US Class Current548/204CPC Class CodesA61P 35/00 Antineoplastic agentsC07D 313/00 Heterocyclic compounds cont...C07D 417/06 linked by a carbon chain co...C07D 493/04 Ortho-condensed systems
