Implantable sensor

• US 6,442,413 B1
• Filed: 05/15/2000
• Issued: 08/27/2002
• Est. Priority Date: 05/15/2000
• Status: Active Grant

• Current Assignee: James H. Silver
• Original Assignee: James H. Silver
• Inventors: Silver, James H.
• Primary Examiner(s): Nasser, Robert L.
• Application Number:
  US09/571,702
• Time in Patent Office: 834 Days
• Field of Search: 600/485-6, 600/345, 600/504-5, 600/347, 600/365
• US Class Current: 600/345
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/6862 Stents
• CPC Class Codes: A61B 5/6876 Blood vessel

Abstract

A sensor is disclosed, for implantation within a blood vessel to monitor an analyte in blood. In one embodiment, the analyte is glucose. A signal indicative of glucose level is transmitted to an external receiver. The signal may also be used to drive an internal or externally worn insulin pump. Methods are also disclosed.

Claims

1. A blood glucose detector for implantation within a blood vessel, comprising:

a support, having a first side for contacting the wall of the vessel and a second side for facing radially inwardly toward the center of the vessel, wherein the support comprises an enlargeable frame and an expandable tubular body; and

a sensor carried by the support and having a sensing surface thereon, wherein the sensing surface is spaced radially inwardly from the first side by a distance of at least about 0.2 mm, such that the velocity of blood in the vessel inhibits obstruction of the sensing surface; and

a tubular sheath on the tubular body, wherein the sheath is on the radially inwardly facing surface of the tubular body.

2. A blood glucose detector as in claim 1, wherein the distance is sufficient to increase the blood flow velocity at the sensing surface to from about 125% to about 200% of the blood flow velocity immediately proximal to the support.

3. A blood glucose detector as in claim 1, further comprising a transmitter on the support, for transmitting information from the sensor to an external receiver.

4. A blood glucose detector as in claim 3, wherein an inductive link supplies power to the transmitter.

5. A blood glucose detector as in claim 1, further comprising a thin film rechargeable battery carried by the support.

6. A blood glucose detector as in claim 1, wherein the support comprises a balloon expandable stent.

7. A blood glucose detector as in claim 1, wherein the support comprises a self expandable stent.

8. A blood glucose detector as in claim 1, wherein the sheath comprises ePTFE.

9. A blood glucose detector as in claim 1, wherein the sensor comprises an analyte permeable membrane and an enzyme gel layer.

10. A blood glucose detector as in claim 9, wherein the analyte permeable membrane comprises a glucose permeable membrane.

11. A blood glucose detector as in claim 9, wherein the enzyme comprises glucose oxidase.

12. An implantable sensor for sensing the presence of an analyte in a vessel, comprising:

a tubular support structure for anchoring the sensor in the vessel, the support having a side wall with a luminal side facing toward the center of the vessel and an abluminal side facing toward the wall of the vessel;

a sensor housing carried by the support structure, the housing comprising gradually sloped surfaces to minimize blood flow turbulence;

a power supply and electrical circuitry in the housing;

a sensing surface exposed to the exterior of the housing, wherein the sensing surface is positioned on the radially inwardly most portion of the luminal side of the housing; and

a tubular sleeve surrounding the tubular support structure, wherein the tubular sleeve is on the radially inwardly facing surface of the tubular support structure.

13. An implantable sensor as in claim 12, wherein the support structure comprises an expandable metal mesh.

14. An implantable sensor as in claim 12, wherein the sensor housing is positioned on the luminal side of the support structure.

15. An implantable sensor as in claim 12, wherein the sensor housing is positioned within an opening on the side wall of the support structure.

16. An implantable sensor as in claim 12, wherein the tubular sleeve comprises ePTFE.

17. An implantable sensor as in claim 12, further comprising an analyte permeable membrane and an enzyme gel layer.

18. An implantable sensor as in claim 17, wherein the enzyme gel layer comprises glucose oxidase.

19. An implantable sensor as in claim 12, wherein the sensor comprises an amperometric sensor.

20. An implantable sensor as in claim 12, wherein the sensor comprises an electrode selected from the group consisting of oxygen electrodes, hydrogen peroxide electrodes, and electrodes with mediated electron transfer.