Apparatus and method for measuring cardiac vagal tone

• US 6,442,420 B1
• Filed: 07/12/2000
• Issued: 08/27/2002
• Est. Priority Date: 11/22/1996
• Status: Expired due to Fees

• Current Assignee: The University Court Of The University Of Glasgow
• Original Assignee: University Court of the University of Glasgow (University of Glasgow)
• Inventors: Little, Christopher John, Julu, Peter Oketa-Onyut
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Assistant Examiner(s): Oropeza, Frances P.
• Application Number:
  US09/308,609
• Time in Patent Office: 776 Days
• Field of Search: 600/509, 600/516, 600/517, 600/518, 600/519
• US Class Current: 600/509
• CPC Class Codes: A61B 5/366 Detecting abnormal QRS complex, e.g. widening
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: A61B 5/4052 efferent nerves, i.e. nerves that relay impulses from the central nervous system
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/417 the bone marrow
• CPC Class Codes: A61B 5/7242 using integration

Abstract

Apparatus for measuring a vagal tone has a detector that detects a QRS waveform of an ECG signal and generates a pulse signal that is integrated by an integrator. The integrator output is passed, in parallel, to a high pass filter and a low pass filter. The filter outputs are passed to respective voltage controlled oscillators (VCOs). The outputs of the VCOs are combined in a phase comparator that generates an output pulse train with the pulse period being proportional to the phase differences of the input signals. The phase comparator output signal is integrated and combined with a DC signal to remove any offset for constant heart rate. The combined signal is applied to a vagal tone gauge, which connects the output into a standard linear vagal tone scale.

Claims

1. An apparatus for providing a measure of vagal tone in a human or animal patient and comprising:

input means for receiving an ECG signal obtained from a patient;

detection means coupled to said input means for detecting QRS waveforms in said ECG signal and for generating timing data indicative of periods between consecutively received QRS waveforms;

frequency demodulation means coupled to said detection means for demodulating said timing data in real time and for generating a signal corresponding to a frequency modulating signal in said ECG signal, wherein said generated signal is used to provide said measure of vagal tone; and

signal processing means for converting the frequency modulating signal into a linear vagal scale (LVS).

2. The apparatus of claim 1, wherein the detection means is arranged to compare received portions of the ECG signal against a stored expected QRS waveform, to identify when a QRS complex is received.

3. The apparatus of claim 1, wherein said timing data comprises a sequence of fixed length pulses which are generated upon receipt of a QRS waveform.

4. The apparatus of claim 1, wherein the frequency demodulation means is a frequency discriminator comprising a differentiator in series with an envelope detector.

5. The apparatus of claim 1, wherein the frequency demodulation means is a phase locked loop (PLL) incorporating a voltage controlled oscillator (VCO) tuned to a nominal constant heart rate.

6. The apparatus of claim 5, wherein a nominal frequency of the VCO is determined by sweeping the VCO frequency across a range until a lock is obtained with the nominal heart rate frequency of said ECG signal.

7. The apparatus of claim 3, wherein said frequency demodulation means comprises a first integrator coupled to the detection means for receiving said fixed length pulses and a high pass filter and a low pass filter coupled separately to the first integrator for respectively receiving an output of the first integrator, an output of the high pass filter being coupled to a first voltage controlled oscillator via a second integrator and an output of the low pass filter being coupled to a second voltage controlled oscillator, outputs of the said first and second voltage controlled oscillators being coupled to respective inputs of a phase comparator arranged to generate at its output a signal indicative of the phase difference between the two input signals.

8. The apparatus of claim 7, wherein said first and second integrators have a time constant between 1.0 and 2.5 seconds so that the outputs of the first and second voltage controlled oscillators are in phase.

9. The apparatus of claim 7, wherein the output from the phase comparator is coupled to a third integrator, which has a time constant selected from the range 1.0 to 2.5 seconds.

10. The apparatus of claim 9, wherein a pre-set DC bias is added to an output of the third integrator to ensure that a resulting summed signal always exceeds zero.

11. The apparatus of claim 1, further comprising a filter coupled to the frequency demodulation means for filtering the frequency modulating signal to remove noise and other unwanted signal components.

12. A method for providing a measure of vagal tone from an ECG recorded from a human or animal patient, the method comprising the steps of:

detecting the occurrence of QRS waveforms in the ECG signal;

generating a timing signal indicative of a time period between consecutively received QRS waveforms;

frequency demodulating said timing signal in real time to obtain a frequency modulation signal, wherein said frequency modulation signal is used to provide said measure of vagal tone; and

converting the frequency modulating signal into a linear vagal scale (LVS) using a signal processing means.

13. The method of claim 12, wherein the method comprises the further step of filtering a signal selected from the group comprising the ECG signal, the timing signal and the frequency modulation signal to remove low frequency components.

14. The method of claim 13, wherein the frequency demodulating step compress integrating the generated timing signal to provide an integrated signal, and separately high pass and low pass filtering in parallel paths the integrated signal to provide a high pass filtered signal and a low pass filtered signal, said high pass filtered signal then being integrated and the resulting integrated signal used to frequency modulate a first carrier signal, and said low pass filtered signal being separately used to frequency modulate a second carrier signal, phase differences between the first and second modulated carrier signals being used to generate an output signal proportional to phase differences between said high pass filtered signal and said low pass filtered signal.

15. An apparatus for providing a measure of vagal tone in a human or animal patient and comprising:

input means for receiving an ECG signal obtained from a patient;

detection means coupled to said input means for detecting QRS waveforms in said ECG signal and for generating timing data indicative of periods between consecutively received QRS waveforms;

frequency demodulation means coupled to said detection means for demodulating said timing data in real time and for generating a signal corresponding to a frequency modulating signal in said ECG signal, wherein said generated signal is used to provide said measure of vagal tone;

wherein said timing data comprises a sequence of fixed length pulses which are generated upon receipt of a QRS waveform; and

wherein said frequency demodulation means comprises a first integrator coupled to the detection means for receiving said fixed length pulses and a high pass filter and a low pass filter coupled separately to the first integrator for respectively receiving an output of the first integrator, an output of the high pass filter being coupled to a first voltage controlled oscillator via a second integrator and an output of the low pass filter being coupled to a second voltage controlled oscillator, outputs of the said first and second voltage controlled oscillators being coupled to respective inputs of a phase comparator arranged to generate at its output a signal indicative of the phase difference between the two input signals.

16. An apparatus for providing a measure of vagal tone in a human or animal patient and comprising:

input means for receiving an ECG signal obtained from a patient;

detection means coupled to said input means for detecting QRS waveforms in said ECG signal and for generating timing data indicative of periods between consecutively received QRS waveforms;

frequency demodulation means coupled to said detection means for demodulating said timing data in real time and for generating a signal corresponding to a frequency modulating signal in said ECG signal, wherein said generated signal is used to provide said measure of vagal tone; and

wherein the frequency demodulation means is a phase locked loop (PLL) incorporating a voltage controlled oscillator (VCO) tuned to a nominal constant heart rate.