Therapeutic delivery systems
First Claim
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1. A method for the controlled delivery of therapeutic compounds to a region of a patient comprising:
- (i) administering to the patient temperature activated gaseous precursor-filled microspheres comprising a therapeutic compound;
(ii) monitoring the microspheres using energy to determine the liquid to gas phase transition and the presence of the microspheres in the region; and
(iii) rupturing the microspheres using energy to release the therapeutic compound in the region.
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Abstract
Therapeutic delivery systems comprising gaseous precursor-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Therapeutic delivery systems comprising gaseous precursor-filled liposomes having encapsulated therein a contrast agent or drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.
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Citations
96 Claims
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1. A method for the controlled delivery of therapeutic compounds to a region of a patient comprising:
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(i) administering to the patient temperature activated gaseous precursor-filled microspheres comprising a therapeutic compound;
(ii) monitoring the microspheres using energy to determine the liquid to gas phase transition and the presence of the microspheres in the region; and
(iii) rupturing the microspheres using energy to release the therapeutic compound in the region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 64, 65, 66, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96)
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- 34. A method for the delivery of therapeutic compounds to a patient comprising administering to the lung of the patient liquid temperature activated gaseous precursor filled microspheres comprising a therapeutic compound.
- 44. A method for delivery of therapeutic compounds to a patient comprising administering to the lung of the patient a liquid temperature activated gaseous precursor filled emulsion comprising a therapeutic compound.
- 53. The method for the delivery of therapeutic compounds to a patient comprising administering to the lung of the patient liquid temperature activated gaseous precursor filled vesicles comprising a therapeutic compound.
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67. A method for the controlled delivery of a drug to an internal bodily region of a patient comprising:
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(a) administering to the patient a drug delivery system comprising a gas-filled lipid containing microsphere prepared by a vacuum drying gas instillation method having encapsulated therein a drug, wherein said gas is provided by a gaseous precursor;
(b) monitoring the microsphere using ultrasound to determine the phase transition of the gaseous precursor from a liquid to a gas and to determine the presence of said microsphere in the region; and
(c) rupturing the microsphere using ultrasound to release the drug in the region. - View Dependent Claims (68, 69, 70, 71, 72, 73, 74, 84, 85, 86)
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- 75. A method of administering drugs to ischemic and diseased tissues comprising delivering to the target site of a patient a drug delivery system comprising gas-filled microspheres having encapsulated therein one or more drugs, wherein said gas is provided by a temperature activated gaseous precursor having an activation temperature of about body temperature.
Specification