End sleeve coating for stent delivery

• US 6,443,980 B1
• Filed: 10/26/2000
• Issued: 09/03/2002
• Est. Priority Date: 03/22/1999
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Tran, The Thomas Trinh, Wang, Lixiao, Williams, Brett A., DiCaprio, Fernando, Yang, Dachuan
• Primary Examiner(s): WEHNER, CARY ELLEN
• Application Number:
  US09/697,194
• Time in Patent Office: 677 Days
• Field of Search: 623/1.11, 623/1.12, 623/1.17, 623/1.23, 606/190, 606/194, 606/198
• US Class Current: 623/1.11
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2002/9583 Means for holding the stent on the balloon, e.g. using protrusions, adhesives or an outer sleeve
• CPC Class Codes: A61F 2002/9586 the means being inside the balloon
• CPC Class Codes: A61L 29/085 Macromolecular materials

Abstract

A stent delivery system which utilizes a stent delivery catheter to deliver a stent into a body lumen. The stent delivery catheter being equipped with at least one stent retaining sleeve. The at least one stent retaining sleeve having an inside surface and an outside surface. The inside surface, outside surface, or both, having a coating which is lubricious.

Claims

1. A stent delivery system comprising a stent delivery catheter which is equipped with at least one stent retaining sleeve, the at least one stent retaining sleeve being further characterized as having an inside surface and an outside surface, said sleeve having a lubricious coating on at least a portion of at least one of said inside surface and said outside surface said lubricious coating comprising at least one selected from the group consisting of hydrogels, homopolymers and copolymers of polyalkylene oxides, homopolymers or copolymers of at least one polymerizable ethylenically unsaturated compound, and mixtures thereof.

2. The stent delivery system of claim 1 wherein said hydrogel is a hydrogel of polyethylene oxide captured in an interpenetrating crosslinked acrylic polymer network by polymerizing a mixture of an acrylic monomer composition comprising a monomer having plural (meth)acrylate groups and polyethylene oxide, thereby providing a hydrogel coating.

3. The stent delivery system of claim 1 wherein said lubricious coating comprises at least one homopolymer or copolymer of polyalkylene oxide.

4. The stent delivery system of claim 3 wherein said lubricious coating is a polyalkylene oxide homopolymer which is a polyethylene glycol.

5. The stent delivery system of claim 1 wherein said lubricious coating comprises at least one polycarboxylic acid selected from maleic acid, fumaric acid and (meth)acrylic acid.

6. The stent delivery system of claim 1 wherein said lubricious coating comprises at least one copolymer of maleic anhydride.

7. The stent delivery system of claim 6 wherein said maleic anhydride copolymer is selected from poly(ethylene-maleic anhydride) copolymers and maleic anhydride-methyl vinyl ether copolymers.

8. A stent delivery system comprising a stent delivery catheter which is equipped with at least one stent retaining sleeve, the at least one stent retaining sleeve being further characterized as having an inside surface and an outside surface, said sleeve having a lubricious coating comprising at least one polymer which moisture cures.

9. A stent delivery system comprising a stent delivery catheter which is equipped with at least one stent retaining sleeve, the at least one stent retaining sleeve being further characterized as having an inside surface and an outside surface, said sleeve having a lubricious coating on at least a portion of at least one of said inside surface and said outside surface said lubricious coating comprising at least one hydrolyzable siloxane and at least one plasticizer.

10. The stent delivery system of claim 9 wherein said at least one hydrolyzable siloxane is an amino terminated hydrolyzable siloxane.

11. The stent delivery system of claim 9 wherein said at least one hydrolyzable siloxane comprises terminal groups selected from C₁ to C₁₂ alkoxy, C₂ to C₄ acryloxy, up to about C₆ (poly)alkoxyalkoxy, phenoxy, amine, oxime, chlorine, fluorine and bromine.

12. The stent delivery system of claim 9 wherein said at least one plasticizer is a silicone oil.

13. A stent delivery system comprising a stent delivery catheter which is equipped with at least one stent retaining sleeve, the at least one stent retaining sleeve being further characterized as having an inside surface and an outside surface, said sleeve having a lubricious coating on at least a portion of at least one of said inside surface and said outside surface wherein said lubricious coating comprises at least one hydrolyzable siloxane and nonhydrolyzable siloxane.

14. The stent delievery system of claim 13 wherein said lubricious coating comprises at least one amino terminated hydrolyzable polydimethylsiloxane and at least one nonhydrolyzable polydimethylsiloxane.

15. A stent delivery system comprising a stent delivery catheter which is equipped with at least one stent retaining sleeve, the at least one stent retaining sleeve being further characterized as having an inside surface and an outside surface, said sleeve having a lubricious coating on at least a portion of at least one of said inside surface and said outside surface said lubricious coating comprises at least one dry lubricant.

16. The stent delivery system of claim 15 wherein said dry lubricant is a hydrocarbon material.

17. The stent delivery system of claim 15 wherein said dry lubricant is a solid lamellar form lubricant.

18. A stent delivery system comprising a stent delivery catheter which is equipped with at least one stent retaining sleeve, the at least one stent retaining sleeve being further characterized as having an inside surface and an outside surface, the inside surface being at least partially coated with a hydrophobic material and the outside surface being at least partially coated with a hydrophilic lubricious coating.

19. The stent delivery system of claim 18 wherein at least one stent retaining sleeve is comprised of an extruded polymeric material.

20. The stent delivery system of claim 18 wherein said lubricious coating is selected from hydrogels, homopolymers and copolymers of polyalkylene oxides, homopolymers or copolymers of at least one polymerizable ethylenically unsaturated compound, and mixtures thereof.

21. The stent delivery system of claim 20 wherein said hydrogel is a hydrogel of polyethylene oxide captured in an interpenetrating crosslinked acrylic polymer network by polymerizing a mixture of an acrylic monomer composition comprising a monomer having plural (meth)acrylate groups and polyethylene oxide, thereby providing a hydrogel coating.

22. The stent delivery system of claim 20 wherein said lubricious coating comprises at least one homopolymer or copolymer of polyalkylene oxide.

23. The stent delivery system of claim 22 wherein said lubricious coating is a polyalkylene oxide homopolymer which is a polyethylene glycol.

24. The stent delivery system of claim 20 wherein said lubricious coating comprises at least one polycarboxylic acid selected from maleic acid, fumaric acid, (meth)acrylic acid, and mixtures thereof.

25. The stent delivery system of claim 18 wherein said lubricious coating comprises at least one copolymer of maleic anhydride.

26. The stent delivery system of claim 25 wherein said maleic anhydride copolymer is selected from poly(ethylene-maleic anhydride) copolymers and maleic anhydride-methyl vinyl ether copolymers.

27. A stent delivery system comprising a stent delivery catheter which is equipped with at least one stent retaining sleeve, the at least one stent retaining sleeve being further characterized as having an inside surface and an outside surface, said sleeve having a hydrophilic lubricious coating on at least a portion of said inside surface, said lubricious coating comprising at least one hydrophilic lubricant selected from the group consisting of esterified polymers, salts, amides, anhydrides, halides, ethers, hydrolyzates, acetals, formals, alkylols, quaternary polymers, diazos, hydrazides, sulfonates, nitrates, ion complexes and mixtures thereof.