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Microfluidic devices and methods for separation

  • US 6,444,461 B1
  • Filed: 09/20/2000
  • Issued: 09/03/2002
  • Est. Priority Date: 04/04/1997
  • Status: Expired due to Term
First Claim
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1. A non-electrophoretic method of separating material in a microfluidic device, the method comprising:

  • flowing at least a first and a second material into contact in the microfluidic device;

    flowing the first material, the second material, or a reaction product resulting from contact of the first and second materials into a microchannel comprising at least one separation region comprising a chromatographic material, wherein the chromatographic material comprises a size-separation matrix, an affinity matrix, a gel-exclusion matrix, or a combination thereof, and whereby the first material, the second material, or the reaction product is separated from at least one other material in the separation region; and

    detecting a resulting separated product.

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