Non-invasive detection of endothelial dysfunction by blood flow measurement in opposed limbs using tracer injection

• US 6,445,945 B1
• Filed: 06/26/2000
• Issued: 09/03/2002
• Est. Priority Date: 06/26/2000
• Status: Expired due to Term

• Current Assignee: Andre Arsenault
• Original Assignee: Andre Arsenault, Institut De Cardiologie De Montrã©Al
• Inventors: Arsenault, André
• Primary Examiner(s): Shaver, Kevin
• Assistant Examiner(s): Natnithithadha, Navin
• Application Number:
  US09/603,554
• Time in Patent Office: 799 Days
• Field of Search: 600/504, 600/507, 600/481, 600/473, 600/476, 600/479, 600/437, 600/438, 600/407, 600/431, 600/420, 600/436
• US Class Current: 600/431
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/02755 Radioactive tracers
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 6/507 for determination of haemodynamic parameters, e.g. perfusion CT

Abstract

Endothelial dysfunction is a known indicator of cornary artery disease. Endothelial dysfunction is detected by measuring tracer presence in arteries following the release of blood flow into the limb after a period of blockage of blood flow into the limb. The blood flow is measured in a pair of laterally opposed limbs, such as the patient'"'"'s forearms, and the tracer presence is compared between both limbs. An efficient tracer is a radionuclide and the non-invasive measurement of the radionuclide is carried out by gamma ray detection.

Claims

1. A method of assessing endothelial dysfunction comprising the steps of:

blocking blood flow in one limb for a first period of time;

releasing the block of blood flow in said one limb;

injecting a bolus of a tracer in a vein such that said bolus is conducted to the heart and evenly distributed to said one limb and an opposed limb via arteries;

measuring a presence of said tracer in said one limb; and

analyzing said presence to assess said endothelial dysfunction.

2. The method as claimed in claim 1, wherein said tracer presence is measured and recorded as a function of time.

3. The method as claimed in claim 2, wherein said step of measuring tracer presence comprises measuring tracer presence in both said limbs, further comprising the step of comparing tracer presence between both said limbs.

4. The method as claimed in claim 3, wherein said tracer comprises a radioactive tracer, said step of measuring comprises measuring radiation emitted from a region of interest in said limbs.

5. The method as claimed in claim 4, wherein said tracer presence is measured and recorded as a function of time.

6. The method as claimed in claim 1, wherein said step of measuring tracer presence comprises measuring tracer presence in both said limbs, further comprising the step of comparing tracer presence between both said limbs.

7. The method as claimed in claim 6, wherein said step of measuring comprises adjusting a position of said limbs with respect to a radiation detector so as to detect radiation with a substantially equal sensitivity for each of said limbs.

8. The method as claimed in claim 7, wherein said limbs comprise arms and said region of interest is a forearm.

9. The method as claimed in claim 8, wherein said forearms are placed palms down on a substantially flat surface in order to detect said region of interest of each one of said forearms.

10. The method as claimed in claim 7, wherein diagnosis of endothelial dysfunction is determined from a steady state measurement of radiation detection.

11. The method as claimed in claim 1, wherein said tracer comprises a radioactive tracer, said step of measuring comprises measuring radiation emitted from a region of interest in said limb.

12. The method as claimed in claim 11, wherein said limb is a forearm, and step of measuring comprises providing a gamma camera with its imaging surface ergonomically positioned with respect to a patient, and placing said forearm on said imaging surface of said gamma camera.

13. The method as claimed in claim 12, wherein two said forearms are substantially extended and placed palms down on said imaging surface in order to detect said region of interest of each one of said forearms.

14. The method as claimed in claim 1, wherein said tracer is a radiation emitter, further comprising measuring an activity of said bolus prior to injection to establish a reference activity level.