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Protein with human choriogonadotropin inhibitory effect

  • US 6,448,022 B1
  • Filed: 07/19/1994
  • Issued: 09/10/2002
  • Est. Priority Date: 12/28/1990
  • Status: Expired due to Fees
First Claim
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1. A method for evaluating inhibition of human chorionic gonadotropin (hCG) production of a subject'"'"'s trophoblast cells comprising the steps of isolating a regulatory polypeptidea) which inhibits, in a dose dependent manner, the production of hCG by human trophoblasts in vitro;

  • b) which substantially inhibits the stimulation of hCG secretion by human trophoblasts caused by exogenous cyclic AMP in vitro;

    c) which does not substantially inhibit the production of human placental lactogen (hPL) by human trophoblasts in vitro; and

    d) which exhibits a molecular weight of about 7,000 to about 10,000 daltons, as determined by ultrafiltration and gel exclusion chromatography;

    from human decidual cells of said subject; and

    quantifying the amount of the regulatory polypeptide produced in vitro by said subject'"'"'s human decidual cells.

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