Hot melt adhesives for dermal application

• US 6,448,303 B1
• Filed: 12/29/2000
• Issued: 09/10/2002
• Est. Priority Date: 12/29/2000
• Status: Expired due to Term

• Current Assignee: Henkel IP & Holding GmbH (Henkel AG & Co KGaA)
• Original Assignee: National Starch and Chemical Investment Holding Corporation
• Inventors: Paul, Charles W.
• Primary Examiner(s): Cain, Edward J.
• Assistant Examiner(s): Yeh, James T.
• Application Number:
  US09/752,260
• Publication Number:
  US 20020128345A1
• Time in Patent Office: 620 Days
• Field of Search: 523/111, 523/105, 526/318.1, 526/318.4, 526/318.5, 526/931, 526/935, 427/208.4, 424/448, 424/449
• US Class Current: 523/105
• CPC Class Codes: A61K 9/7053 obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
• CPC Class Codes: A61K 9/7076 the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
• CPC Class Codes: A61L 15/585 Mixtures of macromolecular compounds
• CPC Class Codes: C08L 53/02 of vinyl-aromatic monomers and conjugated dienes
• CPC Class Codes: C09J 153/00 Adhesives based on block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Adhesives based on derivatives of such polymers

Abstract

A pressure sensitive hot melt adhesive composition which comprises a high molecular weight rubber and less than about 60 parts by weight of a liquid diluent, and has a G′ of less than about 15×10⁴ dynes/cm² at 10 rad/s at 25° C. is useful for adhesive skin application (e.g., surgical tape), including transdermal drug delivery applications.

Claims

1. An pressure sensitive hot melt adhesive composition comprising a high molecular weight rubber and less than about 60 parts by weight of a liquid diluent, and having a G′

of less than 15×

10⁴ dynes/cm² at 10 rad/s at 25°

C.

2. The adhesive of claim 1 comprising from about 1 to about 20 parts by weight of a rubber triblock or radial block copolymer, from 0 to about 20 parts by weight of a high molecular weight diblock rubber, 0 to about 10 parts by weight of other compatible high molecular weight polymers, 0 to about 30 parts by weight of an end block resin, 0 to less that 60 parts by weight oil or other liquid midblock diluent, 0 to about 50 parts by weight of a solid tackifer and 0 to about 3 parts by weight of an anti-oxidant.

3. The adhesive of claim 1 having a peel force of greater than about 100 grams per inch.

4. The adhesive of claim 3 having a peel force of from about 100 grams to about 500 grams per inch.

5. The adhesive of claim 1 which has a mid-block Tg of from about −

30°

C. to about 10°

C.

6. The adhesive of claim 2 wherein the triblock copolymer is styrene-(ethylene-butylene)-styrene.

7. The adhesive of claim 2 wherein the triblock copolymer is styrene-(ethylene-butylene-propylene)-styrene.

8. The adhesive of claim 2 which contains an A-B diblock polymer.

9. The adhesive of claim 8 wherein the diblock copolymer is a styrene-(ethylene-propylene) diblock polymer.

10. The adhesive of claim 2 containing an endblock resin.

11. The adhesive of claim 10 wherein the endblock resin is a homo or copolymer of vinyl toluene, styrene, alpha-methyl styrene, coumarone or indene.

12. The adhesive of claim 1 wherein the liquid diluent is present in an amount of from about 35 to about 55 parts by weight.

13. The adhesive of claim 1 wherein the liquid diluent is oil.

14. The adhesive of claim 1 further comprising a therapeutic agent.

15. The adhesive of claim 14 wherein the therapeutic agent is a pharmacologically active agent.

16. A transdermal drug delivery system comprising the adhesive of claim 14.

17. The transdermal drug delivery system of claim 16 wherein the adhesive serves as a carrier for the therapeutic agent.

18. The transdermal drug delivery system of claim 16 comprising an adhesive layer, and a backing layer.

19. The transdermal drug delivery system of claim 18 further comprising a release layer.

20. A method of administering a therapeutic agent to a patient comprising applying to a body surface of a patient a transdermal drug delivery system comprising the adhesive of claim 14 and a therapeutic agent.