Centering catheter with improved perfusion

• US 6,450,988 B1
• Filed: 12/29/1999
• Issued: 09/17/2002
• Est. Priority Date: 12/29/1999
• Status: Expired due to Term

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Bradshaw, Anthony J.
• Primary Examiner(s): Hayes, Michael J.
• Application Number:
  US09/474,665
• Time in Patent Office: 993 Days
• Field of Search: 604/96.01, 604/101.05, 604/101.01, 604/103.03, 604/103.06, 604/103.07, 604/103.08, 604/916, 600/3
• US Class Current: 604/96.01
• CPC Class Codes: A61M 2025/1047 having centering means, e.g. balloons having an appropriate shape
• CPC Class Codes: A61M 2025/1086 having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
• CPC Class Codes: A61M 2025/1097 with perfusion means for enabling blood circulation only while the balloon is in an inflated state, e.g. temporary by-pass within balloon
• CPC Class Codes: A61M 25/1002 characterised by balloon shape A61M25/1006, A61M25/1009 take precedence
• CPC Class Codes: A61N 2005/1003 having means for centering a radioactive source within the lumen, e.g. balloons
• CPC Class Codes: A61N 5/1002 Intraluminal radiation therapy

Abstract

A centering catheter with engagement knobs to provide improved perfusion in a vessel during intravascular radiation therapy. In one embodiment, a helical centering balloon catheter includes a helical centering balloon formed of helical lobes having a plurality of engagement knobs that outwardly protrude from the helical lobes. The helical lobes form a main spiral perfusion channel for perfusion of blood past the centering catheter. The engagement knobs compliantly engage the vessel walls and offset of the helical lobes such that auxiliary perfusion channels are formed around the engagement knobs between the helical lobes and the walls of the vessel to allow additional perfusion. In the event of a partial obstruction of the spiral channel or a single point failure, the auxiliary perfusion channels allow perfusion past the obstruction.

Claims

1. A catheter for improved perfusion when positioned within a vessel, said catheter comprising:

a segment having lobes which form at least one main perfusion channel, said lobes having a plurality of engagement knobs formed for compliantly engaging the walls of a vessel and forming auxiliary perfusion channels.

2. The catheter of claim 1 wherein said segment is a helical balloon and said lobes are helical lobes.

3. The catheter of claim 2 wherein said engagement knobs are teardrop-shaped, hollow, protrusions from said helical lobes.

4. The catheter of claim 2 wherein said engagement knobs are hemispherical-shaped, hollow, protrusions from said helical lobes.

5. The catheter of claim 1, wherein each of said auxiliary channels is smaller cross-section relative to said at least one main perfusion channel.

6. The catheter of claim 1, wherein said plurality of engagement knobs center said segment within said vessel.

7. A catheter for delivery of intravascular radiation therapy within a vessel comprising:

a flexible, elongate shaft, said shaft having a lumen for receiving a radiation source; and

a segment attached to said shaft, said segment comprising helical lobes which form at least one main spiral perfusion channel, said helical lobes having a plurality of engagement knobs outwardly protruding from said helical lobes for compliantly engaging the walls of said vessel and for forming auxiliary perfusion channels to allow increased perfusion past said catheter.

8. The catheter of claim 7 wherein said segment is an inflatable, helical balloon.

9. The catheter of claim 8 wherein said plurality of engagement knobs are teardrop-shaped, outward, hollow protrusions from said helical lobes.

10. The catheter of claim 8 wherein said plurality of engagement knobs is hemispherical-shaped, outward, hollow protrusions from said helical lobes.

11. The catheter of claim 7, wherein said plurality of engagement knobs center said radiation source, within said vessel.

12. The catheter of claim 7, wherein each of said auxiliary channels is smaller cross-section relative to said at least one spiral perfusion channel.

13. A catheter for delivery of intravascular radiation therapy within a vessel, comprising:

a flexible, elongate shaft, said shaft having a proximal end and distal tip, and a central lumen for receiving a radiation source; and

an inflatable, helical balloon attached to said shaft and located proximal to said distal tip, wherein said inflatable, helical balloon comprises helical lobes which form at least one main spiral perfusion channel, said helical lobes having a plurality of engagement knobs for compliantly engaging the walls of said vessel and for forming auxiliary perfusion channels to allow increased perfusion.

14. The catheter of claim 13 wherein said plurality of engagement knobs is inflatable, outward, hollow protrusions formed integrally from said helical lobes.

15. The catheter of claim 14 wherein when said helical balloon is properly inflated said plurality of engagement knobs outwardly protrude from said helical lobes a distance in the range of 0.25 mm to 0.75 mm.

16. The catheter of claim 14 wherein said plurality of engagement knobs is teardrop-shaped.

17. The catheter of claim 16 wherein said plurality of engagement knobs are spaced within the range of three to five engagement knobs per revolution.

18. The catheter of claim 14 wherein said plurality of engagement knobs is hemispherical-shaped.

19. The catheter of claim 18 wherein said plurality of engagement knobs are spaced within the range of three to five engagement knobs per revolution.

20. The catheter of claim 13, wherein said plurality of engagement knobs center said radiation source, within said vessel.

21. The catheter of claim 13, wherein each of said auxiliary channels is smaller relative to said at least one spiral perfusion channel.

22. An apparatus, comprising:

means for compliantly engaging a wall of a vessel; and

means for forming auxiliary perfusion channels.

23. The apparatus of claim 22 wherein said means for compliantly engaging is a plurality of engagement knobs.

24. The apparatus of claim 23 wherein said plurality of engagement knobs is teardrop-shaped.

25. The apparatus of claim 23 wherein said plurality of engagement knobs are hemispherical-shaped.

26. A catheter, comprising:

a balloon having a plurality of engagement knobs to engage a vessel wall, wherein each of said plurality of engagement knobs is disposed substantially in an axial direction along said balloon with respect to each other, and wherein said plurality of engagement knobs form a plurality of perfusion channels.

27. The catheter of claim 26, further comprising:

a central lumen for receiving a radiation source, wherein said plurality of engagement knobs center said radiation source, when present, within said vessel wall, and wherein said plurality of engagement knobs are disposed substantially in a direction that is perpendicular to said axial direction.

28. The catheter of claim 26, wherein said balloon comprises a helically-shaped balloon that forms a spiral perfusion channel.

29. The catheter of claim 26, wherein each of said plurality of engagement knobs is inflatable, outward, hollow protrusions formed integrally from said balloon, and wherein said axial direction is an axis between a proximal and distal end of said balloon.