Fluid flow control in curved capillary channels

• US 6,451,264 B1
• Filed: 01/28/2000
• Issued: 09/17/2002
• Est. Priority Date: 01/28/2000
• Status: Expired due to Fees

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics Corporation (Roche Holding AG)
• Inventors: Shelton, Jeffrey N., Bhullar, Raghbir Singh, Reiser, Wolfgang O. L.
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): Gordon, Brian R.
• Application Number:
  US09/493,883
• Time in Patent Office: 963 Days
• Field of Search: 422/100, 422/101, 422/102, 422/99, 204/451, 204/454, 204/600, 204/601
• US Class Current: 422/507
• CPC Class Codes: B01L 2300/0861 Configuration of multiple channels and/or chambers in a single devices
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 2400/086 using baffles or other fixed flow obstructions
• CPC Class Codes: B01L 3/502746 characterised by the means for controlling flow resistance, e.g. flow controllers, baffles B01L3/502738 takes precedence

Abstract

A capillary pathway is dimensioned so that the driving force for the movement of liquid through the capillary pathway arises from capillary pressure. A plurality of groups of microstructures are fixed in the capillary pathway within discrete segments of the pathway for facilitating the transport of a liquid around curved portions of pathway. Capillary channels can be coupled between two adjacent groups of microstructures to either the inner and outer wall of the capillary pathway. The width of each capillary channel is generally smaller than the capillary pathway to which it is connected, and can be varied to achieve differences in fill initiation. The grouped microstructures are spaced from each other within each group on a nearest neighbor basis by less than that necessary to achieve capillary flow of liquid with each group. Each group of microstructures are spaced from any adjacent group by an inter-group space greater than the width of any adjacent capillary channels connected to the capillary pathway. Generally, the microstructures are centered on centers which are equally spaced from each other, and microstructures that are located closer to the inner wall of any curve in the capillary pathway are generally smaller than the microstructures located closer to the outer wall. This combination of structural features causes fluids to flow through the capillary pathway so that the rate of flow is somewhat non-uniform as the fluid travels around curved portions of the capillary pathway, the meniscus appearing to pause momentarily at each inter-group space, the flow being somewhat slower near the inner wall of a curved portion than near the outer wall.

Claims

1. A capillary pathway having at least one curved portion, the pathway curved portion comprising a base, an inner wall defined by a first radius from a center point and an outer wall generally concentric about the center point and defined by a second radius greater than the first radius, the inner wall and outer wall being fixed to the base and defining lateral boundaries of the capillary pathway, and a lid extending at least from the inner wall to the outer wall covering the capillary pathway, the capillary pathway including apparatus facilitating the transport of a liquid longitudinally through the pathway comprising:

a plurality of groups of microstructures fixed to the base in the capillary pathway between the inner and outer walls, the microstructures of each group being spaced from each other on a nearest neighbor basis by less than a first distance that is less than that necessary to achieve capillary flow of liquid, each group being confined to a discrete arcuate segment of the at least one curved portion of the capillary pathway, each group being spaced from any adjacent group by a second distance greater than the first distance defining a longitudinal segment of the capillary pathway.

2. The apparatus of claim 1 wherein at least some of the microstructures within at least one of the groups comprises arcuate partitions having longitudinal dimensions about equal to the discrete arcuate segment occupied by the at least one group.

3. The apparatus of claim 1 wherein at least some of the microstructures within at least one of the groups comprises posts.

4. The apparatus of claim 3 wherein the posts arranged in a uniformly spaced triangular close pack configuration.

5. The apparatus of claim 4 wherein at least some of the posts adjacent to either of the walls are joined to the walls.

6. The apparatus of claim 1 wherein the microstructures adjacent to the inner and outer walls are separated from the adjacent walls by a distance less than said first distance.

7. The apparatus of claim 1 wherein the microstructures located closer to the inner wall are smaller than the microstructures located closer to the outer wall.

8. The apparatus of claim 7 wherein the microstructures are centered on centers which are equally spaced from each other.

9. The apparatus of claim 7 further comprising at least one capillary channel coupled to the capillary pathway curved portion between two adjacent groups of the microstructures.

10. The apparatus of claim 9 wherein walls defining lateral boundaries of the at least one capillary channel are closer to each other than are the inner and outer walls of the capillary pathway.

11. The apparatus of claim 10 wherein there are at least two capillary channels coupled to the capillary pathway.

12. The apparatus of claim 11 wherein the walls defining the lateral boundaries of the at least two capillary channels are spaced apart by different distances.

13. A capillary pathway having at least one curved portion, the pathway curved portion comprising a base, an inner wall defined by a first radius from a center point and an outer wall defined by a second radius from the center point greater than the first radius, the inner wall and outer wall being fixed to the base and defining lateral boundaries of the capillary pathway, and a lid extending at least from the inner wall to the outer wall covering the capillary pathway, the capillary pathway including apparatus facilitating the transport of a liquid longitudinally through the pathway comprising:

groups of microstructures fixed to the base of the capillary pathway between the inner and outer walls, the microstructures of each group being spaced from each other on a nearest neighbor basis by less than a first distance that is less than that necessary to achieve capillary flow of liquid, each group being confined to a discrete arcuate segment of the at least one curved portion of the capillary pathway, each group being spaced from any adjacent group by a second distance greater than the first distance defining a longitudinal segment of the capillary pathway.

14. The apparatus of claim 13 further comprising at least one capillary channel coupled to one of the inner and outer wall of the capillary pathway curved portion between two adjacent groups of microstructures.

15. The apparatus of claim 13 wherein the microstructures adjacent to the inner and outer walls are separated from the adjacent walls by a distance less than said first distance.

16. The apparatus of claim 13 wherein walls defining lateral boundaries of the at least one capillary channel are closer to each other than are the inner and outer walls of the capillary pathway.

17. The apparatus of claim 16 wherein there are at least two capillary channels coupled to the capillary pathway.

18. The apparatus of claim 17 wherein the walls defining the lateral boundaries of the at least two capillary channels are spaced apart by different distances.

19. The apparatus of claim 13 wherein at least some of the microstructures within at least one of the groups comprises arcuate partitions having longitudinal dimensions about equal to the discrete arcuate segment occupied by the at least one group.

20. The apparatus of claim 13 wherein at least some of the microstructures within at least one of the groups comprises posts arranged in a uniformly spaced triangular close pack configuration.

21. The apparatus of claim 20 wherein at least some of the posts adjacent to either of the inner and outer walls are joined to the walls.

22. The apparatus of claim 21 wherein the microstructures located closer to the inner wall are smaller than the microstructures located closer to the outer wall.

23. The apparatus of claim 22 wherein the microstructures are centered on centers which are equally spaced from each other.