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Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents

  • US 6,451,346 B1
  • Filed: 12/23/1998
  • Issued: 09/17/2002
  • Est. Priority Date: 12/23/1998
  • Status: Expired due to Fees
First Claim
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1. A pharmaceutical composition for the sustained administration of an effective amount of a protein, comprising an injectable biodegradable polymeric matrix into which said protein has been incorporated, said polymeric matrix having reverse thermal gelation properties and pH-responsive gelation/de-gelation properties;

  • wherein said polymeric matrix is a biodegradable block copolymer comprising;

    (a) 55% to 80% by weight of a hydrophobic A polymer block comprising poly lactide-co-glycolide (PLGA) having an average molecular weight of between 1000-20,000; and

    (b) 20% to 45% by weight of a hydrophilic B polymer block comprising a polyethylene glycol having an average molecular weight of between 500-10,000; and

    wherein said biodegradable block copolymer has ionizable functional groups on one or both ends of the polymer chains.

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