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Simplified mutation detection

  • US 6,451,526 B1
  • Filed: 01/15/1999
  • Issued: 09/17/2002
  • Est. Priority Date: 01/20/1998
  • Status: Expired due to Fees
First Claim
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1. A composition comprising four oligonucleotides, wherein said composition amplifies a region of Factor V genomic sequence during a nucleic acid amplification reaction such that amplified products that are heterologous form stable branching structures, wherein at least two of said four oligonucleotides hybridize to a Factor V genomic sequence between Factor V Leiden mutation site and the Factor V genomic sequence that hybridizes to Primer2, wherein the sequence of Primer2 is set forth in SEQ ID NO:

  • 2, and wherein said region contains the Factor V Leiden mutation site.

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