Electrical gastro-intestinal tract stimulator

• US 6,453,199 B1
• Filed: 09/30/1998
• Issued: 09/17/2002
• Est. Priority Date: 04/01/1996
• Status: Expired due to Fees

• Current Assignee: Valery Ivanovich Kobozev
• Original Assignee: Valery Ivanovich Kobozev
• Inventors: Kobozev, Valery Ivanovich
• Primary Examiner(s): Schaetzle, Kennedy
• Application Number:
  US09/155,820
• Time in Patent Office: 1,448 Days
• Field of Search: 607/133, 607/2, 607/3, 607/36, 607/40, 607/138, 128/899, 128/903, 600/301, 600/546, 600/302, 340/870.1, 340/870.01, 340/573.1, 340/573.5
• US Class Current: 607/40
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control

Abstract

The invention relates to medicine specifically to medical technology, and concerns electrical gastro-intestinal tract and mucous membrane stimulators. The electrical gastro-intestinal tract stimulator comprises a casing (1) with electrodes and in the form of a medicinal capsule containing a power source (4), a control unit (5) of which M outputs are connected to M electrodes (3), a device (6) for receiving signals from internal organs and/or an external transmitter, to (1-N) outputs of which are connected (1-N) inputs of the control unit (5). The electrical stimulator can contain P additional electrodes (7) provided with a coating of microelements or medicinal preparations and connected to P separate outputs of the control unit (5). The electrical stimulator can also contain a signal transmitter (10) designed to transmit signals from the device (6) for receiving signals from internal organs and/or external transmitter and control unit (5) to an external receiver for medical observation and monitoring. The dimensions of the electrical stimulator are restricted by the requirement that it be capable of being introduced into the gastro-intestinal tract orally or rectally or suitable for vaginal use.

Claims

1. An electrical gastro-intestinal tract stimulator comprising a casing with M-electrodes, the casing in the form of a medicinal capsule, containing a power source, a control unit having outputs which are connected to the M-electrodes, and a device for receiving signals having outputs which are connected to N inputs of the control unit, wherein the device for receiving signals further comprises sensors for sensing physiologic parameters of motor-evacuative function and current condition of gastro-intestinal tract organs and for receiving signals from an external transmitter.

2. The electrical stimulator of claim 1, wherein the device for receiving signals further comprises at least one sensor selected from the group consisting of:

a sensor of pressure, a sensor of a pressure gradient, a pH-sensor, an acoustic sensor, a sensor of temperature, a sensor of signals from an external transmitter, a sensor of biopotential, and a sensor of conductivity.

3. The electrical stimulator of claim 1, further comprising a signal transmitter having N-inputs which are connected to N-outputs of the device for receiving signals and the control unit.

4. The electrical stimulator of claim 1, further comprising P-electrodes with a coating of microelements or medicinal preparations.

5. The electrical stimulator of claim 4, further comprising means for demounting the P-electrodes from the stimulator.

6. The electrical stimulator of claim 4, wherein the control unit further comprises a micro-controller having analog-digital amplifiers as inputs, inputs of which amplifiers are inputs of the control unit and are connected to outputs of the device for receiving signals, and the micro-controller having M outputs being outputs of the control unit connected to the M-electrodes and to the P-electrodes of the electric stimulator.

7. The electrical stimulator of claim 1, wherein the control unit further comprises a filtering circuit having an input which is an input of the control unit connected to an output of the device for receiving signals and having an output connected to an input of an amplifier-limiter circuit, and the amplifier-limiter circuit having an output which is an output of the control unit and is connected to a first of said M-electrodes of the electrical stimulator and a common buss connected to a second of said M-electrodes of the electrical stimulator.

8. The electrical stimulator of claim 1, wherein the control unit further comprises an integrator having an input which is a first input of the control unit and is connected to a first output of the device for receiving signals and having an output connected to an input of a threshold circuit, the threshold circuit having an output connected to a first input of an “

or”

circuit, the “

or”

circuit having an output connected to a control input of a pulse series generator, the pulse series generator having outputs which are outputs of the control unit and are connected to the M-electrodes, a first and a second filtering circuits having a common input which is a second input of the control unit connected to a second output of the device for receiving signals the first filtering having an output connected to a set input of an RS-trigger circuit and the second filtering having an output connected to a reset input of the RS-trigger circuit, and the RS trigger circuit having an output connected to a second input of the “

or”

circuit.

9. An in-dwelling electrical gastro-intestinal tract stimulator system including gastrointestinal tract sensors, external receivers and transmitters and an in-dwelling electrical gastro-intestinal tract stimulator, said stimulator comprising:

a casing configured in the form of a medicinal capsule and constructed to be biocompatible with the gastro-intestinal tract;

an electronic stimulator circuit disposed within the casing, the stimulator circuit for electrically stimulating the gastro-intestinal tract and comprising;

an electrical power source for powering a control unit, a receiver device and a transmitter device of the stimulator circuit by means of an electrical connection,

a control unit for controlling the stimulator circuit, the control unit electrically connected to a set of electrical stimulator electrodes, the electrical stimulator electrodes mounted proximate a surface of the casing, and to the receiver device, and to a transmitter device,

a receiver device for receiving signals, and having electrical connections for outputting signals to the control unit and to a transmitter device, and a transmitter device being electrically connected to the receiver device and to the control unit, the transmitter device for sending signals to an external receiver.

10. The stimulator of claim 9, wherein the receiver device of the stimulator circuit receives at least one signal from a sensor of a physiological parameter indicative of motor-evacuative function of the gastro-intestinal tract, the parameter selected from the group consisting of pressure, pressure gradient, pH, sound, temperature, biopotential, conductivity, and any other parameter indicative of gastro-intestinal tract status.

11. The stimulator of claim 9, wherein the signal transmitter of the stimulator circuit receives inputs from the receiver device and the control unit.

12. The stimulator of claim 9, wherein said electrodes further comprises P-electrodes mounted proximate the surface of the casing, the P-electrodes having a coating selected from the group consisting of microelements and medicinal preparations, and being electrically connected to the control unit.

13. The stimulator of claim 9, wherein said electrodes comprises P-electrodes which are demountable.

14. The stimulator of claim 9, wherein the control unit of the stimulator circuit comprises:

a filtering circuit having an input and an output, the input for receiving signals from the receiver device; and

an amplifier-limiter circuit having an input, an output and a common buss, the input connected to the filtering circuit and the output connected to a first of said electrical stimulator electrode and the common buss connected to a second of said stimulator electrode.

15. The stimulator of claim 9, wherein the control unit of the stimulator circuit comprises:

an integrator circuit having an input connected to a first output of said electrical connections for outputting signals of the receiver device and an output connected to an input of a threshold circuit;

the threshold circuit having an output connected to an OR circuit;

the OR circuit having first and second inputs and an output, the first input connected to the output of the threshold circuit, the second input connected to an output of an RS-trigger circuit, and the output connected to an input of a pulse generator;

a pulse generator having a control-input connected to the output of the OR circuit, and outputs connected to said set of electrical stimulator electrodes;

a first and a second parallel filtering circuits, having a common input connection to a second output of the receiver device, and the first filtering circuit having an output connected to a SET-input of the RS-trigger circuit, and the second filtering circuit having an output connected to a RESET-input of the RS-trigger circuit; and

the RS-trigger circuit having the SET-input and RESET-input each separately connected to the output of the first and second filtering circuits, and the output connected to the second input of the OR circuit.

16. The stimulator of claim 9, wherein the control unit comprises:

amplifiers 1 to N, each having an input connected to a signal source selected from the group consisting of a feed-back circuit, the receiver device and the transmitter device, and each having a digital output connected to an input of a microprocessor; and

a microprocessor, having N-inputs 1 to N, and M-outputs 1 to M and P-outputs 1 P, and the M-outputs being connected to said electrical stimulator electrodes, and the P-outputs being connected to a set of P-electrodes.

17. The control unit of claim 16, wherein the amplifiers 1 to N further comprise analog-digital converters.

18. The stimulator of claim 9, wherein the receiver device of the stimulator circuit receives an externally transmitted signal.

19. An electrical gastro-intestinal tract stimulator device capable of being introduced into the gastro-intestinal tract orally or rectally or suitable for vaginal use, comprising:

a casing in the form of a capsule with M-electrodes and P-electrodes and containing a power source;

a control unit having N-inputs, M-outputs and P-outputs, and the M-outputs connected to the M-electrodes, and the P-outputs connected to the P-electrodess provided with a coating of microelements or medicinal preparations;

a receiver device for receiving signals from internal organs and an external transmitter, and having the N-outputs connected to the N-inputs of the control unit; and

a signal transmitter device for sending signals from the receiver device and the control unit to an external receiver for medical observation and monitoring.