Apparatus and method for diagnosis of cardiac disease using a respiration monitor

• US 6,454,719 B1
• Filed: 08/01/2000
• Issued: 09/24/2002
• Est. Priority Date: 08/01/2000
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Greenhut, Saul E.
• Primary Examiner(s): Nasser, Robert L.
• Assistant Examiner(s): MALLARI, PATRICIA C
• Application Number:
  US09/630,298
• Time in Patent Office: 784 Days
• Field of Search: 600/529, 600/484, 600/547, 600/481, 607/17, 607/19, 607/20
• US Class Current: 600/484
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/091 Measuring volume of inspired or expired gases, e.g. to determine lung capacity
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy

Abstract

The cardiac condition of a patient is determined by a cardiac monitor apparatus using a respiration parameter such as a current respiration signal or a respiration rate. The variability of the respiration parameter is used to generate a signal indicative of the current heart failure status of the patient, and more particularly whether the patient'"'"'s condition has improved, worsened, or remained unchanged over a predetermined time period. The circuitry for detecting the respiration parameter may be implanted in the patient, for example as part of a pacemaker, while at least some of the analyzing circuitry may be external and remote from the patient. Alternatively the whole device may be implantable.

Claims

1. A cardiac monitoring apparatus that monitors the cardiac condition of a patient comprising:

a respiration sensor adapted to sense the respiration of the patient and generating corresponding respiration signal;

an analyzer that analyzes said respiration signals to determine a long term behavior of said respiration signals, and generates a respiration variability signal when said behavior conforms to predetermined criteria indicative of the respiration variability; and

an output device receiving said respiration variability signal and generating an output signal based on said respiration variability signal and indicative of a congestive heart failure status of said patient.

2. The apparatus of claim 1 further comprising an implantable cardiac device arranged and constructed to generate cardiac stimulation signals for the patient'"'"'s heart wherein said respiration sensor is disposed inside said implantable cardiac device and said analyzer is disposed at a location remote from the patient, said apparatus further comprising a communication channel for transmitting said respiration signals to said analyzer.

3. The apparatus of claim 1 wherein said respiration sensor and at least a portion of said analyzer are disposed in said device and said output device is disposed at a remote location.

4. The apparatus of claim 1 wherein said analyzer includes a memory storing said respiration signals over a predetermined time period, a calculator determining said respiration variability signal, wherein said analyzer is adapted to evaluate a trend of said variability over an extended time period.

9. The apparatus of claim 1 wherein said respiration sensor includes an impedance detector that detects and measures a transthoracic impedance of the patient as a function of respiration.

11. The apparatus of claim 1 wherein said respiration sensor includes a respiration rate calculator that calculates a respiration rate for the patient and wherein said analyzer is adapted to analyze said respiration rate to determine said congestive heart failure status of the patient.

5. A cardiac monitoring apparatus that monitors the cardiac condition of a patient comprising:

a respiration sensor adapted to sense the respiration of the patient and generating corresponding respiration signal;

an analyzer that analyzes said respiration signals to determine a long term behavior of said respiration signals, and generates a respiration variability signal when said behavior conforms to predetermined criteria indicative of the respiration variability; and

an output device receiving said respiration variability signal and generating an output signal based on said respiration variability signal indicative of a cardiac condition of said patient;

wherein said analyzer includes a frequency detector that detects and analyzes the frequency of said respiration signals and a power calculator for calculating the power levels above and below a cutoff frequency.

6. The apparatus of claim 5 wherein said frequency detector further comprises a comparator that compares a ratio of the power levels of high and low frequency signal components, said ratio being indicative of said respiration variability signal.

7. The apparatus of claim 6 wherein said analyzer further comprises a trend detector coupled to said comparator and arranged to detect a trend in said ratio, and wherein said respiration variability signal corresponds to said trend.

8. The apparatus of claim 7 wherein said output device generates a first output signal if said respiration variability signal indicates that said ratio has been decreasing over time and a second output signal if said respiration variability signal indicates that said ratio has been increasing over time.

10. A cardiac monitoring apparatus that monitors the cardiac condition of a patient comprising:

a respiration sensor adapted to sense the respiration of the patient and generating corresponding respiration signal;

an analyzer that analyzes said respiration signals to determine a long term behavior of said respiration signals, and generates a respiration variability signal when said behavior conforms to predetermined criteria indicative of the respiration variability; and

an output device receiving said respiration variability signal and generating an output signal based on said respiration variability signal indicative of a cardiac condition of said patient;

wherein said respiration sensor includes a tidal volume detector that detects and measures a tidal volume of the patient and a calculator that calculates said respiration signal from said tidal volume.

12. A cardiac monitoring apparatus for a patient comprising:

a respiration sensor that senses a breathing pattern of the patient and generates a corresponding respiration signal;

an analyzer that receives said respiration signal and analyzes said signal to determine if said breathing pattern corresponds to preselected criteria, said analyzer generating an indication signal; and

an output device coupled to said analyzer that receives said indication signal, said output device generating an output corresponding to said indication signal, said output corresponding to a congestive heart failure (CHF) status.

13. The apparatus of claim 12 wherein said respiration sensor includes an impedance detector that detects a transthoracic impedance of the patient and a calculator that calculates said respiration signal from said transthoracic impedance.

14. The apparatus of claim 12 wherein said respiration sensor includes a tidal volume detector that detects a tidal volume of the patient and a calculator that calculates a respiration signal based on said tidal volume.

15. The apparatus of claim 12 wherein said analyzer calculates a rate of respiration of the patient from said respiration signal.

16. The apparatus of claim 15 wherein said analyzer includes a variability detector that receives said rate and calculates a variability of said respiration rate.

17. The apparatus of claim 16 further comprising a trend detector that detects a trend in said variability, said trend being related to the CHF status of the patient.

19. The apparatus of claim 12 wherein said analyzer further includes a variability detector that analyzes a variability of said breathing pattern.

20. The apparatus of claim 19 wherein said analyzer generates a first indication signal if said ratio decreases over time, said first indication signal being indicative of an improved CHF status of the patient, and a second signal if said variability decreases over time, said second signal being indicative of a worsened CHF status.

21. The apparatus of claim 12 wherein said respiration monitor is implantable in the patient.

18. A cardiac monitoring apparatus for a patient comprising:

a respiration sensor that senses a breathing pattern of the patient and generates a corresponding respiration signal;

an analyzer that receives said respiration signal and analyzes said signal to determine if said breathing pattern corresponds to preselected criteria, said analyzer including a calculator that calculates a rate of respiration of the patient from said respiration signal, an da variability detector that receives said rate and calculates a varibility of said respiration rate, said analyzer generating an indication signal indicative of the cardiac condition of the patient based on said variability; and

an output device coupled to said analyzer that receives said indication signal, said output device generating an output corresponding to said indication signal;

wherein said variability detector includes a power detector that detects a relative power of high respiration rate signals and a relative power of low respiration signals, said high an low respiration rate signals defined as being higher an lower than a preselected rate threshold, respectively.

22. A method of determining the cardiac condition of a patient comprising:

detecting a respiration signal indicative of a current respiration of the patient;

analyzing said respiration signal to determine if said respiration signal meets predetermined criteria related to a congestive heart failure (CHF) status of the patient; and

generating an indication signal corresponding to said CHF status and based on said analysis.

23. The method of claim 22 wherein said step of detecting said respiration signal comprises detecting a transthoracic impedance of the patient, said transthoracic impedance being dependent on said respiration signal.

24. The method of claim 22 wherein said step of analyzing includes detecting a variability of said respiration signal.

25. A method of determining the cardiac condition of a patient comprising:

detecting a respiration signal indicative of a current respiration of the patient;

analyzing said respiration signal to determine if said respiration signal meets predetermined criteria related to the cardiac condition of the patient; and

generating an indication signal corresponding to said cardiac condition and based on said analysis;

wherein said step of analyzing includes detecting a high signal power of respiration signals having a frequency above a predetermined threshold and detecting a low signal power of respiration signals having a frequency below said predetermined threshold.

26. The method of claim 25 wherein said step of analyzing further includes determining a ratio of said high signal power and low signal power.

27. The method of claim 26 wherein said step of analyzing further comprises analyzing a trend of said ratio.

28. The method of claim 27 further comprising generating a first signal indicative of improved CHF status of the patient and a second signal indicative of worsened CHF status based on said trend.

29. A cardiac monitoring apparatus for a patient comprising:

a respiration sensor that senses a breathing pattern of the patient and generates a corresponding respiration signal;

an analyzer that receives said respiration signal and analyzes said signal to determine if said breathing pattern corresponds to preselected criteria, calculates a rate of respiration of the patient from said respiration signal calculates a variability of said respiration rate and generates an indication signal indicative of a congestive heart failure status of the patient based on said variability; and

an output device coupled to said analyzer that receives said indication signal, said output device generating an output corresponding to said indication signal.

30. The apparatus of claim 29 wherein said respiration sensor includes an impedance detector that detects a transthoracic impedance of the patient and a calculator that calculates said respiration signal from said transthoracic impedance.

31. The apparatus of claim 29 wherein said respiration sensor includes a tidal volume detector that detects a tidal volume of the patient and a calculator that calculates a respiration signal based on said tidal volume.

32. A method of determining a cardiac condition of a patient comprising:

detecting a respiration signal indicative of a current respiration of the patient;

analyzing said respiration signal including detecting a variability of said respiration signal to determine if said respiration signal meets predetermined criteria related to the congestive heart failure status of the patient; and

generating an indication signal corresponding to said congestive heart failure status and based on said analysis.

33. The method of claim 32 wherein said step of detecting said respiration signal comprises detecting a transthoracic impedance of the patient, said transthoracic impedance being dependent on said respiration signal.