Microfabricated injectable drug delivery system
First Claim
1. A system for injectable drug delivery, comprising:
- an implantable device having at least one microchannel and containing in at least one drug to be delivered by osmotic pressure, valves in said device for at least controlling generation of said osmotic pressure, an externally located controller for activating said valves, and a piston located in said at least one microchannel intermediate said osmotic device and said at least one drug to be delivered.
4 Assignments
0 Petitions
Accused Products
Abstract
A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.
120 Citations
18 Claims
-
1. A system for injectable drug delivery, comprising:
-
an implantable device having at least one microchannel and containing in at least one drug to be delivered by osmotic pressure, valves in said device for at least controlling generation of said osmotic pressure, an externally located controller for activating said valves, and a piston located in said at least one microchannel intermediate said osmotic device and said at least one drug to be delivered. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
-
-
13. In an implantable, osmotic driven drug delivery device, the improvement comprising:
-
a plurality of microchannels located in said device, each microchannel having a drug-filled section, each microchannel having an osmotic pressure generating section, each microchannel having a piston located intermediate said osmotic pressure generating section and said drug-filled section, said piston being constructed to prevent fluid leakage therepast, valve means for controlling activation of said osmotic pressure generating section, and valve means for controlling discharge from said drug-filled section. - View Dependent Claims (14, 15, 16, 17, 18)
-
Specification