Illumination box and camera system

• US 6,454,939 B1
• Filed: 01/12/2000
• Issued: 09/24/2002
• Est. Priority Date: 05/13/1998
• Status: Expired due to Fees

• Current Assignee: Lawrence Livermore National Security LLC (Government of the United States of America)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Jensen, Wayne A., Kelly, Fredrick R., Klunder, Gregory L., Wiefel, Michael H., Haas, Jeffrey S., Bushman, John F.
• Primary Examiner(s): Savage, Matthew O.
• Assistant Examiner(s): OCAMPO, MARIANNE S
• Application Number:
  US09/482,183
• Time in Patent Office: 986 Days
• Field of Search: 210/198.3, 210/198.2, 210/658, 210/656, 210/85, 210/94-95, 206/456, 403/66--67, 422/61, 422/68.1, 422/70, 422/82.05, 422/102, 422/104, 356/344, 356/244, 355/18, 355/21, 355/67, 355/69, 355/75, 250/428, 250/559.08, 250/239, 362/3, 362/257, 362/276, 73/233.6, 73/15.6
• US Class Current: 210/198.3
• CPC Class Codes: G01N 2030/0095 Separation specially adapted for use outside laboratory, e.g. field sampling, portable equipments
• CPC Class Codes: G01N 30/88 Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
• CPC Class Codes: G01N 30/90 Plate chromatography, e.g. thin layer or paper chromatography
• CPC Class Codes: G01N 30/92 Construction of the plate
• CPC Class Codes: G01N 30/94 Development
• CPC Class Codes: G01N 30/95 Detectors specially adapted therefor; Signal analysis

Abstract

A hand portable, field-deployable thin-layer chromatography (TLC) unit and a hand portable, battery-operated unit for development, illumination, and data acquisition of the TLC plates contain many miniaturized features that permit a large number of samples to be processed efficiently. The TLC unit includes a solvent tank, a holder for TLC plates, and a variety of tool chambers for storing TLC plates, solvent, and pipettes. After processing in the TLC unit, a TLC plate is positioned in a collapsible illumination box, where the box and a CCD camera are optically aligned for optimal pixel resolution of the CCD images of the TLC plate. The TLC system includes an improved development chamber for chemical development of TLC plates that prevents solvent overflow.

Claims

1. A hand portable thin-layer chromatography illumination box and camera system for on-site field analysis comprising:

a portable housing having a top section and a bottom section, wherein an inner peripheral surface of said top section slidably engages on an outer peripheral surface of said bottom section thereby allowing said housing to change from a fully expanded state to a reduced volume state by slidably collapsing said top section over said bottom section and change dimensions of said box,

at least one light source in the housing positioned at the top section thereof,

a means for placing a thin-layer chromatography plate into the housing disposed at the bottom section of the housing and below the at least one light source;

an aperture on an upper surface of the top section of the housing above the at least one light source for imaging the thin-layer chromatography plate with a camera, and

a charge-coupled device (CCD) camera having its lens positioned at the aperture.

2. The illumination box as recited in claim 1, wherein the at least one light source in the housing comprises at least one visible light source and at least one ultraviolet light source.

3. The illumination box as recited in claim 1, wherein the means for placing a thin-layer chromatography plate comprises a sliding drawer.

4. The illumination box as recited in claim 1, wherein the dimensions of the box are optically aligned for optimal resolution of the images of the chromatography plate.

5. The illumination box as recited in claim 1, wherein the box has dimensions of about 16 cm×

12 cm×

14 cm in its expanded state.

6. The illumination box as recited in claim 1, wherein the at least one light source is battery powered.