Polyether block amides containing active substances

• US 6,455,059 B1
• Filed: 05/07/2001
• Issued: 09/24/2002
• Est. Priority Date: 11/12/1998
• Status: Expired due to Fees

• Current Assignee: Bayer AG
• Original Assignee: Bayer AG
• Inventors: Wagner, Joachim, Pudleiner, Heinz, Dujardin, Ralf, Simon, Joachim, Albers, Reinhard, Hobler, Hartwin
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): FUBARA, BLESSING M
• Application Number:
  US09/831,227
• Time in Patent Office: 505 Days
• Field of Search: 424/405, 424/409, 424/484, 424/486
• US Class Current: 424/405
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/206 Biguanides, e.g. chlorohexidine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/45 Mixtures of two or more drugs, e.g. synergistic mixtures
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: C08L 77/12 Polyester-amides

Abstract

Molding compositions comprising polyether block amide and homogeneously distributed antimicrobially active substances are disclosed. The compositions are suitable for molding a variety of articles, notably medical articles.

Claims

1. A thermoplastic molding composition comprising:

(a) a polyether block amide polymer having repeat units represented by the following formula (I),

 

wherein

A is a residue of a polyamide having 2 terminal carboxylic acid groups, and

B is a residue of a polyoxyalkylene glycol having terminal OH groups; and

(b) at least one homogeneously distributed antimicrobially active substance selected from at least one of (i) nalidixic acid, pipemidics acid, cinoxacin, ciprofloxacin, norfloxacin, ofloxacin, perfloxacin and enoxacin;

(ii) aminoglycosides;

(iii) macrolides;

(iv) polypeptides;

(v) lincomycins;

(vi) antimycobacterial agents; and

(vii) fusidic acid,

provided that said polyether block amide (a) and said antimicrobially active substance (b) have an interfacial energy of 0.5 to 30 mN/m.

2. A molded article comprising the composition of claim 1.

3. The composition of claim 1 wherein said active substance (b) is present in an amount such that a molded article prepared from said composition is free of surface colonization by bacteria for a period of 2 to 4 weeks.

4. The composition of claim 1 wherein said active substance (b) is present in an amount of 0.01 to 10 percent by weight, based on the weight of said composition.

5. The composition of claim 1 wherein said active substance (b) is selected from at least one of nalidixic acid, pipemidic acid, cinoxacin, ciprofloxacin, norfloxacin, ofloxacin, perfloxacin and enoxacin.

6. The composition of claim 5 wherein said active substance (b) is ciprofloxacin.

7. The composition of claim 1 wherein said polyether block amide (a) and said antimicrobially active substance (b) have an interfacial energy of 5 to 15 mN/m.

8. The composition of claim 1 wherein the amount of said polyoxyalkylene glycol used in the preparation of said polyether block amide polymer (a) is from 5 to 85 percent by weight, based on the weight of said polyoxyalkylene glycol and said polyamide having 2 terminal coarboxylic acid groups.

9. The composition of claim 1 wherein the amount of said polyoxyalkylene glycol used in the preparation of said polyether block amide polymer (a) is from 10 to 50 percent by weight, based on the weight of said polyoxyalkylene glycol and said polyamide having 2 terminal coarboxylic acid groups.

10. The molded article of claim 2 wherein said molded article is a catheter.

11. A method of preparing a molded article comprising extruding the composition of claim 1.