Implant device with a retinoid for improved biocompatibility

• US 6,455,062 B1
• Filed: 08/21/2001
• Issued: 09/24/2002
• Est. Priority Date: 08/11/1997
• Status: Expired due to Term

• Current Assignee: Allergan Incorporated (Abbvie Incorporated)
• Original Assignee: Allergan Incorporated (Abbvie Incorporated)
• Inventors: Olejnik, Orest, Hughes, Patrick M., Kent, John S.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Sheikh, Humera N.
• Application Number:
  US09/935,360
• Time in Patent Office: 399 Days
• Field of Search: 424/428, 424/422, 424/423, 424/426, 424/427, 514/725, 514/954, 514/955
• US Class Current: 424/423
• CPC Class Codes: A61K 31/07 Retinol compounds, e.g. vitamin A retinoic acids A61K31/203
• CPC Class Codes: A61K 31/192 having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid cannabinoids A61K31/658
• CPC Class Codes: A61K 31/455 Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61L 2300/428 Vitamins, e.g. tocopherol, riboflavin
• CPC Class Codes: A61L 2300/442 Colorants, dyes
• CPC Class Codes: A61L 2300/604 Biodegradation
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

An implant device is provided which incorporates a retinoid for improving the biocompatibility of the device in tissue. The device may be bioerodible for the purpose of systemically or locally releasing a therapeutic agent in tissue or it may be a permanent implant which includes a surface treated with a retinoid for increasing the biocompatibility thereof.

Claims

1. An implantable device for providing systemic or local release of a therapeutic agent in tissue, the device comprising:

a therapeutic agent;

an implant sized for insertion into tissue in which systemic or local release of the therapeutic agent is desired, said implant including means for providing controlled release of the therapeutic agent wherein said means comprises a biodegradable polymer; and

a retinoid means, separate from the therapeutic agent and homogeneously distributed throughout the implant, for improving biocompatibility of the implant in the tissue.

2. The implantable device according to claim 1 wherein said implant comprises a plug.

3. The implantable device according to claim 1 wherein said implant comprises a sclera plug.

4. The implantable device according to claim 1 wherein said implant comprises a cardiac valve component.

5. The implantable device according to claim 1 wherein said implant comprises a stent.

6. The implantable device according to claim 1 wherein said implant comprises an endovascular stent.

7. The implantable device according to claim 1 wherein said implant comprises a stud.

8. The implantable device according to claim 1 wherein said implant comprises a prosthesis.

9. The implantable device according to claim 1 wherein said implant comprises a joint prosthesis.