L-8-oxo-7-propyl-7,8-dihydro-(9H)-guanosine

• US 6,455,690 B1
• Filed: 06/15/2000
• Issued: 09/24/2002
• Est. Priority Date: 10/16/1996
• Status: Expired due to Fees

• Current Assignee: Anadys Pharmaceuticals Inc. (Roche Holding AG)
• Original Assignee: Anadys Pharmaceuticals Inc. (Roche Holding AG)
• Inventors: Ramasamy, Kanda, Wang, Guangyi, Averett, Devron, Tam, Robert
• Primary Examiner(s): Geist, Gary
• Assistant Examiner(s): CRANE, LAWRENCE E
• Application Number:
  US09/594,647
• Time in Patent Office: 831 Days
• Field of Search: 536/27.13, 536/27.81
• US Class Current: 536/27.81
• CPC Class Codes: A61K 31/52 Purines, e.g. adenine
• CPC Class Codes: A61K 31/522 having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 31/7076 containing purines, e.g. adenosine, adenylic acid
• CPC Class Codes: A61K 31/7115 Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
• CPC Class Codes: C07H 19/052 Imidazole radicals
• CPC Class Codes: C07H 19/056 Triazole or tetrazole radicals
• CPC Class Codes: C07H 19/16 Purine radicals
• CPC Class Codes: C07H 19/24 Heterocyclic radicals containing oxygen or sulfur as ring hetero atom

Abstract

Novel nucleosides having the structure of Formula 1 and Formula 2 are contemplated. In one aspect of the invention, controlled release dosage forms are particularly contemplated. Further, alternative routes of administration of the nucleosides having the structure of Formula 1 or Formula 2 are contemplated.

Claims

1. A nucleoside having the structure of Formula 1: