Automatic analyzer for monitoring pipetting operations

• US 6,456,944 B1
• Filed: 09/20/1999
• Issued: 09/24/2002
• Est. Priority Date: 09/30/1998
• Status: Expired due to Term

• Current Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Original Assignee: Roche Diagnostics Corporation (Roche Holding AG)
• Inventors: Gödl, Fritz, Burkhardt, Claudius
• Primary Examiner(s): NOLAND, THOMAS
• Application Number:
  US09/399,554
• Time in Patent Office: 1,100 Days
• Field of Search: 702/32, 702/25, 702/30, 702/31, 738/630.1, 738/630.2, 738/630.3, 738/642.1, 738/642.2, 738/642.3, 738/642.4, 738/642.5, 422/67, 422/68.1
• US Class Current: 702/32
• CPC Class Codes: G01N 2035/1018 Detecting inhomogeneities, e.g. foam, bubbles, clots
• CPC Class Codes: G01N 35/00594 Quality control, including calibration or testing of components of the analyser
• CPC Class Codes: G01N 35/00603 Reinspection of samples
• CPC Class Codes: G01N 35/1016 Control of the volume dispensed or introduced

Abstract

An automatic analyzer for the assay of liquid samples pipetted from a container into a mixing chamber includes a controller for controlling the operation of the analyzer in response to sensors that monitor the functions of the analyzer. Within the analyzer, the responses of the sensors are evaluated and, when such responses do not meet prescribed criteria, error messages are provided. In the disclosed embodiments, the controller is implemented using at least one program-controlled processor. In order to monitor the pipetting operations in an effective manner, the automatic analyzer, in one embodiment, uses a plurality of operation and monitoring control units which operate independently of one another. Each of these units is by a central processing unit.

Claims

1. An automatic analyzer for the assay of liquid samples, said analyzer comprising:

a pipetting device for removing said liquid sample from a container and for transferring the sample,

a mixing chamber having a reaction cuvette for receiving said sample,

means for controlling the operation of the analyzer,

sensors for monitoring the function of the analyzer,

means for evaluating possible monitoring results and for delivering possible error messages, said means including at least one program-controlled processor,

a plurality of operation and monitoring control units which are independent from each other,

a central processing unit for activating each of said control units by a start command and for carrying out a process which ends with the delivery of a corresponding mode signal (S1 to S7) to said central processing unit, and

a combinatory logic circuit which is connected to at least two of said control units, said logic circuit combining messages delivered by said control units as a logical AND and delivering to said central processing unit an output mode signal which corresponds to the combinatory result, and

reactions of the analyzer each of which corresponds to each one of the mode signals (S1 to S7) being provided in said central processing unit.

2. The analyzer of claim 1, wherein said analyzer further comprises:

a first unit that causes and monitors rinsing a pipetting needle;

a second unit that causes and monitors a controlled immersion of the pipetting needle into a liquid;

a third unit that causes and monitors aspiration of liquid into the pipetting needle, and

a fourth unit that causes and monitors ejection of the aspirated liquid from the pipetting needle.

3. The analyzer of claim 2, wherein said analyzer further comprises an optical sensor to monitor the ejection of the aspirated liquid from the pipetting needle.

4. The analyzer of claim 1, wherein said control units and said combinatory logic circuit are discrete electronic circuits.

5. The analyzer of claim 1, wherein said control units and said logic circuit are self-contained programs associated with a superior control program for a program-controlled processor.