Vascular inducing implants

• US 6,458,092 B1
• Filed: 09/30/1998
• Issued: 10/01/2002
• Est. Priority Date: 09/30/1998
• Status: Expired due to Fees

• Current Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Original Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Inventors: Weiser, Michael F., Gambale, Richard A., Forcucci, Stephen J., Forde, Sean, Choh, Richard T.
• Primary Examiner(s): KENNEDY, SHARON E
• Application Number:
  US09/164,173
• Time in Patent Office: 1,462 Days
• Field of Search: 604/526, 604/890.1, 604/891.1, 604/93.01, 606/198, 606/22, 606/48, 606/185
• US Class Current: 604/22
• CPC Class Codes: A61B 17/00234 for minimally invasive surgery A61B17/0218, A61B17/0469, A61B17/12013, A61B17/1285, A61B17/29, A61B17/320016 take precedence
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/2493 Transmyocardial revascularisation [TMR] devices
• CPC Class Codes: A61F 2/94 Stents retaining their form, i.e. not being deformable, after placement in the predetermined place
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2230/0076 ellipsoidal or ovoid
• CPC Class Codes: A61F 2230/0091 helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body

Abstract

Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.

Claims

1. An implant device for implantation into tissue comprising:

an implant having a first configuration with a first profile and a second configuration having a second profile that is greater than the first profile whereby surrounding tissue into which the implant is placed is stressed and irritated sufficiently to cause an injury response including thrombus formation that initiates angiogenesis; and

an angiogenic substance for promoting angiogenesis associated with the implant.

2. An implant device as defined in claim 1 wherein the angiogenic substance is joined to the device by a coating.

3. A device as defined in claim 1 wherein the angiogenic substance becomes associated with the device after the device is delivered into the tissue.

4. An implant device as defined in claim 3 wherein the body of the device defines a hollow interior and the angiogenic substance is inserted into the hollow interior after the device is implanted.

5. An implant device as defined in claim 1, wherein the body of the device defines a hollow interior and an angiogenic substance loaded into the hollow interior prior to implantation of the device.

6. An implant device as defined in claim 5 further comprising at least one opening in the body of a size to permit the angiogenic substance to transfer from the interior to the outside of the device.

7. An implant device as defined in claim 1 wherein the angiogenic substance becomes associated with the implant after it is implanted.

8. An implant device as defined in claim 1 wherein the implant is a cylinder.

9. An implant as defined in claim 1 further comprising a spring that is resiliently expandable from the first configuration to the second configuration.

10. An implant device as defined in claim 1 wherein the implant is flexible after assuming the second configuration.