Drug delivery through microencapsulation
First Claim
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1. An implantable drug delivery device comprising:
- a microencapsulated drug contained within at least one capsule, a carrier fluid that will dissolve the drug when freed from the capsule, a drug releaser for freeing the microencapsulated drug from the capsule, a reservoir in which the carrier fluid dissolves the drug, and an electromechanical pump to convey the dissolved drug to a catheter, through which the drug is delivered.
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Abstract
An implantable drug delivery device comprising a microencapsulated drug contained within at least one capsule, a carrier fluid that will dissolve the drug when freed from the capsule, a drug releaser for freeing the microencapsulated drug from the capsule, a reservoir in which the carrier fluid dissolves the drug, and an electromechanical pump to convey the dissolved drug to a catheter, through which the drug is delivered to a target site within a patient.
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Citations
34 Claims
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1. An implantable drug delivery device comprising:
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a microencapsulated drug contained within at least one capsule, a carrier fluid that will dissolve the drug when freed from the capsule, a drug releaser for freeing the microencapsulated drug from the capsule, a reservoir in which the carrier fluid dissolves the drug, and an electromechanical pump to convey the dissolved drug to a catheter, through which the drug is delivered. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for drug delivery by an implantable electromechanical pump and a catheter having a discharge portion and having a proximal end coupled to said pump, said method comprising the steps of:
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implanting said pump outside a patient site;
surgically implanting said catheter so that said discharge portion lies adjacent a predetermined infusion site in the patient;
supplying to a reservoir at least one capsule containing a drug;
supplying to the reservoir a carrier fluid capable of dissolving the drug;
breaking open the capsule so as to free the drug from the capsule;
dissolving the drug in the carrier fluid to form a mixture;
and pumping the mixture to and through the discharge portion of the catheter and to the infusion site. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. An implantable reagent delivery and sensor device comprising:
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a microencapsulated reagent contained within at least one capsule, a sensor having a reservoir that contains the microencapsulated reagent, a drug releaser for freeing the microencapsulated reagent from the capsule, the freed reagent being capable of reacting with a first substance to produce a second substance that is directly proportional to the amount of the first substance, the sensor capable of measuring the amount of the second substance. - View Dependent Claims (32, 33, 34)
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Specification