Retinal stimulator

• US 6,458,157 B1
• Filed: 07/29/1998
• Issued: 10/01/2002
• Est. Priority Date: 08/04/1997
• Status: Expired due to Term

• Current Assignee: NewSouth Innovations Pty Limited (University Of New South Wales)
• Original Assignee: Gregg Jørgen Suaning
• Inventors: Suaning, Gregg Jørgen
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US09/123,995
• Time in Patent Office: 1,525 Days
• Field of Search: 607/53, 607/54, 607/116, 607/148, 607/149, 623/4, 623/4.1, 623/6.63, 128/898, 128/899, 600/554, 600/558, 600/559
• US Class Current: 623/6.63
• CPC Class Codes: A61F 2/14 Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
• CPC Class Codes: A61N 1/0543 Retinal electrodes
• CPC Class Codes: A61N 1/36046 of the eye

Abstract

An apparatus facilitating the delivery of electrical stimulation to physiologically excitable retinal nerve cells includes: (a), a receiver/decoder/stimulator comprising a semiconductor integrated circuit and other components hermetically sealed within a capsule, implanted and fixed within the eye of the patient such that it may receive power, and decode information from (b), an externally worn image processor/encoder/transmitter comprising an image detector, an image processor capable of translating the image into an array of discreet pixels of varying intensity, encoding the pixel information into a series of discreet data bursts representing the chosen current amplitude, pulse duration, stimulating electrode or electrodes, and reference electrode or electrodes, and transmitting this data to the receiver/decoder/stimulator through a tuned, inductive communication link such that the system may deliver controlled, charge balanced, diphasic, constant current stimulus pulses to (c), discreet metallic electrodes on a flexible, multiple site electrode array implanted on, near or under the surface of the retina. The apparatus provides for flexibility in the external image processing system such that future advancements in processing techniques shall not require revision surgery or modification to the implanted receiver/decoder/stimulator. Safeguards to protect the patient from the delivery of inappropriate stimulus are incorporated into the apparatus, and a method of external collection of diagnostic data from the implanted receiver/decoder/stimulator is described.

Claims

1. A system for stimulating physiologically excitable cells of a retina of an eye to generate a psychophysical response, said system comprising:

a transmitter for transmitting into the eye, an electromagnetic radio frequency carrier modulated by an encoded visual image signal, and

an implant within the eye for receiving the modulated carrier and demodulating the encoded visual image signal therefrom, and for decoding the encoded visual image signal and converting the decoded signal into an electrical stimulation signal for delivery to the physiologically excitable cells of the retina to thereby generate the psychophysical response.

2. A system as claimed in claim 1, further comprising an image processor for producing the encoded visual image signal by converting an initial input image into pixel information relating to an array of discreet pixels, each having a particular intensity, and by thereafter encoding said pixel information into said encoded visual image signal.

3. A system as claimed in claim 2, wherein said implant further comprises an array of electrodes for the delivery of the electrical stimulation signal to the physiologically excitable cells of the retina, said array of electrodes being ill corresponding, geometric relationship with the array of discreet pixels associated with the initial input image.

4. A system as claimed in claim 3, wherein the carrier is said modulated by consecutive sequences of discrete data bursts, each of said sequence representing visual image signal parameters including current amplitude and pulse duration for one or more addressed ones of each of said electrodes.

5. A system as claimed in claim 3, wherein the electrical stimulation signal is charge balanced by providing a capacitive element in series with each of an alternate. opposite two groups of said electrodes, and each of said groups delivers the biphasic relationship.

6. A system as claimed in claim 1, wherein said implant further comprises an error detection circuit for preventing the delivery of the electrical stimulation signal, whenever at least a part of said encoded visual image signal violates a pre-determined encoding protocol.

7. A system as claimed in claim 6, wherein said pre-determined encoding protocol includes allowable numbers of cycles of the radio frequency carrier.

8. A system as claimed in claim 1, said system further comprising an external telemetry detector, for receiving auxiliary data transmitted from the implant to derive changes in electrical potential, said changes being associated with the electrical stimulation signal.

9. A system as claimed in claim 8, wherein said telemetry detector is configured to controllably enable adjustment of predetermined procedures and parameters associated with the electrical stimulation signal.

10. A system as claimed in claim 1, wherein said implant further comprises means for receiving and rectifying energy from the radio frequency carrier to supply power for said implant.

11. A system as claimed in claim 1, wherein said implant comprises materials incompatible with ocular tissue, said materials being encapsulated within a hermetically sealed ocular compatible chamber.

12. A system as claimed in claim 1, wherein said implant is positioned within the ocular anatomy, at least by way of a magnetic force.

13. A system for stimulating physiologically excitable cells of a retina of an eye, said system comprising:

an image processor for processing a captured image into an array of discrete pixels, each having a particular intensity,

an encoder for encoding said array of discrete pixels into an encoded data signal,

a transmitter for transmitting the encoded data signal in sequential bursts, to a receiver within the eye for receiving the encoded data signal transmitted from the transmitter,

a decoder within the eye for converting the encoded data signal received by the receiver into stimulus signals, and

a stimulator within the eye for selectively stimulating the physiologically excitable cells of the retina as a function of the stimulus signals.

14. A system for stimulating physiologically excitable cells of a retina of an eye, said system comprising:

an image processor for processing a captured image into an array of discreet pixels, each having a particular intensity,

an encoder for encoding said array of discrete pixels into an encoded data signal,

a transmitter for transmitting the encoded data signal in sequential bursts to a receiver within the eye for receiving the encoded data signal transmitted from the transmitter,

a decoder within the eye for converting the encoded data signal received by the receiver into stimulus signals whenever a pre-determined data protocol associated with encoded data signal is satisfied, and

a stimulator within the eye for selectively stimulating the physiologically excitable cells of the retina as a function of the stimulus signals.

15. A system for stimulating the physiologically excitable cells of a retina of an eye, said system comprising:

an image processor for processing a captured image into an array of discreet pixels, each having a particular intensity,

an encoder for encoding said array of discreet pixels into an encoded data signal,

a transmitter for transmitting the encoded data signal in sequential bursts to a receiver within the eye for receiving the encoded data signal transmitted from the transmitter,

a decoder within the eye for converting'"'"'the encoded data signal received by the receiver into stimulus signals, and

a stimulator within the eye for selectively stimulating the physiologically excitable cells of the retina as a function of the stimulus signals and for charge balancing said stimulation signal by grouping each of said electrodes into two or more groups and providing each group with a series arranged capacitive element.

16. A retinal stimulation system for use in a patient, said system comprising:

an implant for receiving power and configuration data transmitted by an external device having the ability to process, encode and transmit an external image,

an external telemetry detector for receiving data from said implant and for deriving a change in electrical potential across the stimulation circuit, and

an external processor for controlling adjusting the image processing procedure and stimulus parameters of the implant.

17. An eye implant for stimulating a retina of an eye to generate a psychophysical response, said implant comprising:

a receiver for receiving an electromagnetic radio frequency carrier modulated by an encoded visual image signal, and for demodulating the encoded visual image signal therefrom,

a decoder for converting the encoded visual image signal into stimulus signals, and

a stimulator for selectively stimulating the retina as a function of the stimulus signals.

18. A method of enabling a phosphene to be produced, in response to stimulation of nerve cells in a being, said method comprising the steps of.

obtaining and dividing a visual image into an array of discrete regions,

extracting visually related intensity data for each of said discrete regions,

producing a sequence of encoded image data comprising at least, said intensity data and a unique address for each of said regions,

transmitting said encoded image data over a tuned inductive link,

receiving and decoding said image data into a plurality of stimulus signals having both position and intensity attributes, and

applying said stimulus signals to nerve cells which are capable of producing the phosphene.

19. A method of stimulating a retina of an eye to generate a psychophysical response, said method comprising the steps of:

transmitting an electromagnetic radio frequency carrier modulated by an encoded visual image signal into the eye; and

within the eye, receiving the modulated carrier, demodulating the encoded visual image signal therefrom, decoding the encoded visual image signal, converting the decoded signal into an electrical stimulation signal and delivering the electrical stimulation signal to the retina to thereby generate the psychophysical response.

20. A method of stimulating a retina of an eye to generate a psychophysical response, said method comprising the steps of:

processing a captured image into an array of discrete pixels, each having a particular intensity,

encoding said array of discrete pixels into an encoded data signal;

transmitting the encoded data signal in sequential bursts, to a receiver within the eye,

receiving the encoded data signal by said receiver and converting the encoded data signal into stimulus signals; and

selectively stimulating the retina as a function of the stimulus signals.