Dressing and preparation delivery system

• US 6,458,380 B1
• Filed: 11/09/2000
• Issued: 10/01/2002
• Est. Priority Date: 11/09/2000
• Status: Expired due to Fees

• Current Assignee: Richard Leaderman
• Original Assignee: Richard Leaderman
• Inventors: Leaderman, Richard
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): EVANS, CHARESSE L
• Application Number:
  US09/710,345
• Time in Patent Office: 691 Days
• Field of Search: 424/400, 424/401, 424/422, 424/423, 424/434, 424/435, 424/443, 424/445, 424/484, 424/489, 424/49, 424/77
• US Class Current: 424/443
• CPC Class Codes: A61K 6/20 Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
• CPC Class Codes: A61K 6/30 Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/22 Peroxides; Oxygen; Ozone
• CPC Class Codes: A61L 15/60 Liquid-swellable gel-forming materials, e.g. super-absorbents
• CPC Class Codes: A61L 15/64 specially adapted to be resorbable inside the body
• CPC Class Codes: A61L 24/0031 Hydrogels or hydrocolloids
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: C08L 1/02 Cellulose; Modified cellulose
• CPC Class Codes: C08L 1/08 Cellulose derivatives
• CPC Class Codes: C08L 2201/06 Biodegradable
• CPC Class Codes: C08L 33/06 of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
• CPC Class Codes: C08L 33/20 Homopolymers or copolymers of acrylonitrile C08L55/02 takes precedence
• CPC Class Codes: C08L 33/26 Homopolymers or copolymers of acrylamide or methacrylamide
• CPC Class Codes: C08L 71/02 Polyalkylene oxides
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin

Abstract

A dressing and method of treating wounds is provided. The dressing can comprise water-soluble or swellable polymers which are capable of forming a viscous aqueous or non-aqueous solution and form a gel, particularly a foam form of the gel. The dressing can be constructed in the form of a sponge or sheet impregnated with the gel, or coated onto a non-porous, porous or micro-porous substrate. The dressing can also be provided in a form of a dehydrated powder, such as one which can be sprinkled under a flap of tissue and which will hold the flap down as a substitute for the use of stitches. Wounds treated with dressings in accordance with embodiment of the invention will tend to heal without the formation of a typical hard scab. The gel provides an excellent surface from which to apply tooth whitener to the teeth. The solubility of the material may be adjusted through the addition of non-interacting secondary raw materials to the liquid state formulation mix, or sprayed over the completed product to form a bi-layer, tri-layer, or other multiple layer material that can demonstrate varied solubility and degradation over time when compared to a single formulation mix and subsequent freeze drying or other means of processing to form the desired product.

Claims

1. A method of treating a wound with a dressing material, comprising:

forming a gel with a gel forming, amount of a water soluble or water swellable pharmaceutically acceptable polymer;

dehydrating the gel to a preparation in the form a foam or powder form of the gel material;

applying the preparation in either a rehydrated or non-rehydrated form to the wound site;

the foam or powder in a suitable form, that it will adhere to a wound site for at least 24 hours and during that time, enhance healing of the wound and help prevent infection of the wound.

2. The method of claim 1, wherein the preparation is applied to a wound in the oral cavity.

3. The method of claim 1, wherein the polymer component comprises a member selected from the group consisting of polyoxyethylene—

polyoxypropylene copolymers, polysaccharides, poly(ethylene oxide), acrylamide polymers, and salts and derivatives thereof.

4. The method of claim 1, wherein the polymer component comprises vinyl polymers or salts or derivatives thereof.

5. The method of claim 1, wherein the polymer component comprises salt or acid forms of polymers of acrylic or methacrylic acids crosslinked with divinyl glycol.

6. The method of claim 1, wherein the polymer component comprises the acid form of polycarbophil.

7. The method of claim 1, wherein the polymer component consists essentially of the acid form of polycarbophil.

8. The method of claim 1, wherein the gel is formed with at least about 0.1% by weight polycarbophil.

9. The method of claim 1, wherein the gel is formed with about 0.1 to 2.0% by weight polycarbophil.

10. The method of claim 1, wherein the gel is formed with about 0.3% to 0.7% by weight polycarbophil.

11. The method of claim 1, wherein the polymer component comprises at least one member selected from the group consisting of collagen, gelatin, fibronectin, cellulose, hydroxypropyl cellulose (HPC), hydroxypropylmethyl cellulose (HPMC), methyl cellulose (MC), ethyl cellulose (EC), carboxymethyl cellulose (CMC) and carboxyethyl cellulose (CEC).

12. The method of claim 1, wherein the gel is incorporated applied to a pharmaceutically acceptable carrier substrate prior to dehydration.

13. The method of claim 1, wherein the dehydrated gel is applied to a pharmaceutically acceptable carrier substrate after dehydration.

14. The method of claim 1, wherein the gel is dehydrated into the form of a powder and the wound comprises the area under a flap of tissue and the powder is applied to the wound and holds the flap in place.

15. The method of claim 1, comprising including an anti-bacterial agent in the dressing material.

16. A dressing for treating wounds, comprising the dehydrated form of a gel formed from a biocompatable polymer and water, said dehydrated gel being in the form of a foam sheet or a powder that will adhere to tissue at a wound site, promote healing of a wound covered by the dressing and help protect the wound from infection.

17. A wound dressing comprising the acid form of polycarbophil in the form of a gel, foam or powder.

18. A method of treating a wound, comprising:

applying the dehydrated powder or foam form of an aqueous based gel of a polymer comprising polycarbophil to the wound.

19. The method of claim 18, wherein the wound is in the oral cavity.

20. The method of claim 18, wherein the wound comprises a flap of tissue, comprising applying the powder form of a dehydrated gel under the fly of tissue to hold down the flap, help prevent infection and increase the rate of healing of the wound.

21. A tooth whitener, comprising a layer of polycarbophil having tooth whitening material combined therewith.

22. The tooth whitener of claim 21, wherein the tooth whitening material comprises buffered or unbuffered hydrogen peroxide.

23. The tooth whitener of claim 22, wherein one side of the layer of gel is backed with material which will not adhere to the teeth or gums.

24. The tooth whitener of claim 21, wherein the layer of polycarbophil comprises dehydrated polycarbophil gel.

25. A method of whitening teeth, comprising forming a gel with a gel forming amount of a water soluble or water swellable pharmaceutically acceptable polymer;

dehydrating the gel and forming a sheet of dehydrated gel material;

combining the gel with tooth whitening material before of after the gel is dehydrated; and

adhering the layer of gel with tooth whitener to the teeth.

26. The method of claim 25, wherein the tooth whitener is added after the layer is formed.

27. The method of claim 25, wherein the tooth whitener is added before the layer is formed.

28. The method of claim 25, wherein the gel comprises polycarbophil.

29. The method of claim 25, wherein the tooth whitener comprises hydrogen peroxide.

30. The method of claim 25, wherein the tooth whitener comprises a peroxide containing material.