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Liquid pharmaceutical compositions comprising thyroid hormones

  • US 6,458,842 B1
  • Filed: 07/31/1996
  • Issued: 10/01/2002
  • Est. Priority Date: 02/01/1994
  • Status: Expired due to Fees
First Claim
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1. A stable liquid oral dosage pharmaceutical composition, said composition comprising at least one thyroid hormone selected from the group consisting of L-3,5,3′

  • ,5′

    -tetraiodothyronine (levothyroxine or LT4), L-3,5,3′

    -triiodothyronine (liothyronine or LT3), L-3,3′

    ,5′

    -triiodothyronine (LrT3), L-3,5-diiodothyrone (LT2), pharmaceutically acceptable salts thereof, and mixtures thereof;

    from about 40% to about 96% of ethanol by volume;

    a pH adjusting agent so that the measured pH of the composition is from about 9 to about 12; and

    from about 4% to about 50% water by volume.

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