Apparatus for access to interstitial fluid, blood, or blood plasma components
First Claim
Patent Images
1. A transcutaneous implant comprising:
- an access component to provide a stable dermal interface;
a central housing disposed within the access component, the central housing having a first end for external access and a second end;
a first septum disposed within the central housing; and
a filtration membrane disposed at the second end of the central housing to allow analyte in bodily fluid to enter a reservoir formed by the filtration membrane, the first septum and the central housing, wherein the filtration membrane includes a first material to promote neovascularization.
0 Assignments
0 Petitions
Accused Products
Abstract
A transcutaneous implant having a stable biological seal at the skin interface, obviating the need for puncturing the skin to obtain fluid samples is described. The implant includes an advanced filtration membrane to promote neovascularization which eliminates mass transfer problems by promoting the development of capillary networks with transcapillary mass transfer rates high enough to insure rapid exchange of analyte between blood and the device. Additionally the membrane provides a bioprotective layer which prevents transport of proteins and cellular components into the device.
-
Citations
58 Claims
-
1. A transcutaneous implant comprising:
-
an access component to provide a stable dermal interface;
a central housing disposed within the access component, the central housing having a first end for external access and a second end;
a first septum disposed within the central housing; and
a filtration membrane disposed at the second end of the central housing to allow analyte in bodily fluid to enter a reservoir formed by the filtration membrane, the first septum and the central housing, wherein the filtration membrane includes a first material to promote neovascularization. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
-
-
43. A sensing system having a transcutaneous implant device comprising:
-
an electroenzymatic sensor;
a transcutaneous implant device, including;
an access component to provide a stable dermal interface;
a central housing disposed within the access component, the central housing having a first end for external access and a second end;
a first septum disposed within the central housing; and
a filtration membrane disposed at the second end of the central housing to allow analyte in bodily fluid to enter a reservoir formed by the filtration membrane, the first septum and the central housing, wherein the filtration membrane includes a first material to promote neovascularization. - View Dependent Claims (44, 45, 46, 47, 48)
-
-
49. An implant to deliver fluid to, withdraw fluid from, or monitor a fluid of an animal body, the implant comprising:
-
an access component to provide a stable dermal interface wherein the access, component includes a housing having a first end which is externally accessible, capable of being without puncturing the skin of the animal body and a second end;
a septum, disposed within the housing, to provide a liquid tight seal; and
a membrane disposed at, and coupled to the second end of the housing wherein the membrane includes a first material that promotes neovascularization when located within the animal body and wherein the membrane, the septum and the housing form a reservoir. - View Dependent Claims (50, 51, 52, 53, 54, 55)
-
-
56. An implant to deliver fluid to, withdraw fluid from, or monitor a fluid of an animal body, the implant comprising:
-
an access component to provide a stable dermal interface wherein the access component includes a housing having a first end which is externally capable of accessible without puncturing the skin of the animal body and a second end;
a septum, disposed within the housing, to provide a liquid tight seal; and
a membrane disposed at, and coupled to the second end of the housing wherein the membrane includes a first material that retards avascularization when located within the animal body and wherein the membrane, the septum and the housing form a reservoir. - View Dependent Claims (57, 58)
-
Specification