Device and method for infusion of small molecule insulin mimetic materials
First Claim
1. A medication delivery device for delivering a small molecule insulin mimetic material to a body of an individual, the device comprising:
- a housing containing a driving mechanism;
a reservoir that is coupled to the driving mechanism in the housing for holding the small molecule insulin mimetic material to be infused into the body of the individual; and
a controller to control the driving mechanism to expel the small molecule insulin mimetic material from the reservoir into the body of the individual.
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Accused Products
Abstract
A medication delivery device for delivering a small molecule insulin mimetic material to a body of an individual includes a housing, a reservoir and a controller. The housing contains a driving mechanism, and the reservoir is coupled to the driving mechanism in the housing for holding the small molecule insulin mimetic material to be infused into the body of the individual. The controller controls the driving mechanism to expel the small molecule insulin mimetic material from the reservoir into the body of the individual. Preferably, the medication delivery device is an infusion pump. In particular, the driving mechanism is a syringe type drive actuator, or a gas generator. The driving mechanism may also utilize iontophoresis or passive trans-dermal delivery. In addition, the driving mechanism is controlled to infuse the small molecule insulin mimetic material in a continuous, near-continuous, intermittent and pulsatile manner. The driving mechanism may also be controlled to deliver discrete, user settable boluses. Preferably, the small molecule insulin mimetic material is L-783,281. Also, the small molecule insulin mimetic material may be an analog of L-783,281. In addition, the small molecule insulin mimetic material may be infused with at least one additional component such as insulin, insulin analogs and insulin related peptides. Preferably, the small molecule insulin mimetic material binds to β sub-units of an insulin receptor site. However, the small molecule insulin mimetic material may bind to α a sub-units of an insulin receptor site. Alternatively, the small molecule insulin mimetic material is a trans-membrane insulin mimetic material that binds to at least one β sub-unit and at least one α a sub-unit of an insulin receptor site.
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Citations
43 Claims
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1. A medication delivery device for delivering a small molecule insulin mimetic material to a body of an individual, the device comprising:
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a housing containing a driving mechanism;
a reservoir that is coupled to the driving mechanism in the housing for holding the small molecule insulin mimetic material to be infused into the body of the individual; and
a controller to control the driving mechanism to expel the small molecule insulin mimetic material from the reservoir into the body of the individual. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of delivering a small molecular insulin mimetic material to a body of an individual, the method comprising the steps of:
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providing a medication delivery device with a driving mechanism;
holding the small molecule insulin mimetic material to be infused into the body of the individual in a reservoir;
coupling the reservoir to the driving mechanism; and
controlling the driving mechanism to expel the small molecule insulin mimeric material from the reservoir into the body of the individual. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A medication delivery device for delivering a small molecule insulin mimetic material to a body of an individual, the device comprising:
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a housing containing a driving mechanism;
a reservoir that is coupled to the driving mechanism in the housing for holding the small molecule insulin mimetic material to be infused into the body of the individual;
a controller to control the driving mechanism to expel the small molecule insulin mimetic material from the reservoir into the body of the individual; and
an input from a sensor sensitive to small molecule insulin mimetic material levels in the body, and wherein the input from the sensor is used to control the controller of the medication delivery device. - View Dependent Claims (43)
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Specification