Cannula operated pinch valve

• US 6,461,345 B1
• Filed: 11/09/1999
• Issued: 10/08/2002
• Est. Priority Date: 11/16/1998
• Status: Expired due to Fees

• Current Assignee: Merck Sharp & Dohme Corporation (Merck & Co., Inc.)
• Original Assignee: Merck & Co., Inc.
• Inventors: Kath, Gary S.
• Primary Examiner(s): Bockelman, Mark
• Application Number:
  US09/436,416
• Time in Patent Office: 1,064 Days
• Field of Search: 604/256, 604/167.02, 604/167.03, 604/403, 137/800, 251/339, 251/336, 251/4-10, 251/349, 251/350, 251/355, 215/247-249
• US Class Current: 604/403
• CPC Class Codes: B01L 2400/0655 pinch valves
• CPC Class Codes: B01L 3/02 Burettes; Pipettes
• CPC Class Codes: B01L 3/508 rigid containers not provided for above
• CPC Class Codes: F16K 15/1825 for check valves with flexible valve members
• CPC Class Codes: G01N 35/1079 with means for piercing stoppers or septums

Abstract

There is disclosed a pinch valve for allowing access to a sterile reaction vessel using a cannula. The valve remains closed until a cannula is inserted. Upon removal of the cannula, the valve automatically closes maintaining the sterile or otherwise controlled conditions of the reaction vessel.

Claims

1. A cannula operated, pinch valve, for use with a reaction vessel, the pinch valve comprising:

a) a section of PTFE tubing being compressed along a middle region thereof;

b) a valve-sealing, elastomeric material through which the PTFE tubing is fitted, the middle region of the tubing being compressed and sealed, wherein the elastomeric material keeps the tubing compressed and sealed;

c) a shrink-sleeve of suitable dimension fully enclosing the elastomeric material and tubing to form the pinch valve; and

d) a cap fitted over the pinch valve to seal the pinch valve to the reaction vessel,

wherein the reaction vessel is sealed, the seal being broken by insertion of the cannula through the tubing into the reaction vessel, and the reaction vessel being re-sealed upon removal of the cannula therefrom.

2. The cannula operated, pinch valve according to claim 1, wherein the valve-sealing, elastomeric material is silicon.

3. The cannula operated, pinch valve according to claim 2, wherein the cannula is tapered for insertion into the tubing.

4. The cannula operated, pinch valve according to claim 3, wherein the reaction vessel is a vial.

5. The cannula operated, pinch valve according to claim 4, wherein the structural integrity of the pinch valve is maintained by the shrink-sleeve.

6. A cannula operated, pinch valve for fitting into a reaction vessel, the pinch valve comprising:

a) a length of PTFE tubing being compressed along a middle region thereof, a lower region of the tubing that extends below the middle region being fitted with a tapered seat;

b) a valve-sealing, elastomeric material through which the PTFE tubing is fitted, the middle region of the tubing being compressed and sealed, wherein the elastomeric material keeps the tubing compressed and sealed;

c) a shrink-sleeve of suitable dimension fully enclosing the elastomeric material and tubing to form the pinch valve;

d) a vent hole located in the lower region of the tubing;

e) a sipper tube attached to the tapered seat of the tubing; and

f) a cap fitted over the pinch valve to seal the pinch valve and sipper tube into the reaction vessel,

wherein the reaction vessel is sealed, the seal being broken by insertion of the cannula through the tubing into the reaction vessel, and the reaction vessel being re-sealed upon removal of the cannula therefrom.

7. The cannula operated, pinch valve according to claim 6, wherein the valve-sealing, elastomeric material is silicon.

8. The cannula operated, pinch valve according to claim 7, wherein the reaction vessel is a vial.

9. The cannula operated, pinch valve according to claim 8, wherein the structural integrity of the pinch valve is maintained by the shrink-sleeve.

10. The cannula operated, pinch valve according to claim 9, wherein the reaction vessel is a vial.

11. The cannula operated, pinch valve according to claim 10, wherein the sipper tube is fitted with a porous frit of sintered glass.

12. A method of adding material to and removing material from a sealed reaction vessel, the reaction vessel being fitted with a cannula operated, pinch valve characterized as a length of PTFE tubing being compressed along a middle region thereof;

a valve-sealing, elastomeric material through which the PTFE tubing is fitted, the middle region of the tubing being compressed and sealed;

a shrink-sleeve of suitable dimension fully enclosing the elastomeric material and tubing to form the pinch valve; and

a cap fitted over the pinch valve to seal the pinch valve into the reaction vessel, the method of adding and removing material, comprising the steps of;

a) inserting a tapered cannula into the PTFE tubing through the compressed, middle region of the tubing into the reaction vessel, wherein the seal of the pinch valve is broken;

b) adding material to or removing material from the reaction vessel by way of the cannula; and

c) withdrawing the cannula from the PTFE tubing through the compressed, middle region of the tubing to re-seal of tubing,

wherein material cannot be added to or removed from the reaction vessel.