Fluid-jet deposition of radioactive material

• US 6,461,433 B1
• Filed: 07/05/2000
• Issued: 10/08/2002
• Est. Priority Date: 05/27/1998
• Status: Expired due to Term

• Current Assignee: Eckert & Ziegler BEBIG S.A (Eckert & Ziegler AG)
• Original Assignee: International Brachytherapy Company
• Inventors: Fox, James Edward, Russell, John L. Jr., Carden, John L. Jr., Willis, Michael, Hudd, Alan Lionel
• Primary Examiner(s): Crispino, Richard
• Assistant Examiner(s): TADESSE, YEWEBDAR T
• Application Number:
  US09/609,834
• Time in Patent Office: 825 Days
• Field of Search: 118/688, 118/679, 118/680, 118/681, 118/323, 427/5, 427/2.14, 427/2.11
• US Class Current: 118/688
• CPC Class Codes: A61N 2005/1019 Sources therefor
• CPC Class Codes: A61N 5/1001 using radiation sources introduced into or applied onto the body; brachytherapy
• CPC Class Codes: G21G 4/08 specially adapted for medical application radiation therapy using radioactive sources A61N5/10

Abstract

A method and apparatus for precisely applying radioactive material to a substrate such as a brachytherapy device is disclosed. A radioactive fluid adapted to cure rapidly is deposited as discrete dots onto a surface with a fluid-jet printhead. The apparatus comprises a fluid-jet printhead in communication with a chamber containing radioactive fluid to be applied by the printhead. The printhead is microprocessor driven, and the microprocessor may be provided with feedback from a station where the radioactivity deposited on a preceding substrate in a batch is measured, permitting the system to be recalibrated on an ongoing basis as the batch of printed devices is produced. Compensation for attenuation of radiation by a casing may also be made part of the feedback technique. Also disclosed is a brachytherapy device having printed on a surface dots of radiation-emitting material, in a pattern comprising various bands, dots or areas. Fluids suitable for printing by a fluid-jet printhead comprise a binder such as an acrylic resin or silicate, and a radioactive salt, compound or complex, dissolved in a radiation resistant solvent. Alternative fluids comprise radioactive salts, compounds, or complexes adsorbed onto a microparticulate carrier, or elemental microparticles, dispersed in a rapidly curable radiation-resistant fluid medium.

Claims

1. An apparatus for depositing discrete dots of radioactive material onto a surface of a substrate, said apparatus comprising:

(a) a fluid-jet printhead;

(b) a reservoir adapted for containing and dispensing radioactive fluid, having an opening communicating with said fluid-jet printhead;

(c) means for positioning and repositioning said printhead relative to the substrate;

(d) computing means, in communication with said printhead and with said positioning means (c), for controlling relative positions of said printhead and the substrate, and for controlling fi of said printhead, so as to apply predetermined amounts of said radioactive fluid onto said substrate at predetermined positions; and

(e) means for measuring the radioactivity; and

(f) computing means, receptive to data supplied by said measuring means (e) and controlling the amount of radioactive fluid subsequently deposited by said printhead in accordance with said data.

3. The apparatus of claim 1, further comprising:

(g) curing means for curing said radiation resistant curable liquid by applying heat, irradiation or catalysis to said substrate.

5. The apparatus of claim 1, wherein the radioactive fluid comprises:

a radioactive isotope; and

a rapidly curable radiation-resistant curable liquid.

6. The apparatus of claim 5, wherein said radiation-resistant curable liquid comprises a binder.

7. The apparatus of claim 6, wherein said binder is an acrylic resin or sodium silicate.

8. The apparatus of claim 5, wherein:

said radioactive isotope is in the form of;

(a) a solution of a radioactive complex, (b) a solution of a radioactive salt, (c) a radioactive isotope adsorbed onto a powder, or (d) a powder consisting essentially of radioactive and nonradioactive isotopes of an element.

9. The apparatus of claim 1, wherein said radioactive fluid comprises a solution of (NH₃)₄Pd(OH)₂.

10. The apparatus of claim 1 wherein said radioactive fluid comprises a powder having radioactive iodine or radioactive palladium absorbed thereto.

2. An apparatus for depositing discrete dots of radioactive material onto a surface of a substrate, said apparatus comprising:

(a) a fluid-jet printhead;

(b) a reservoir adapted for containing and dispensing radioactive fluid, having an opening communicating with said fluid-jet printhead;

(c) means for positioning and repositioning said printhead relative to the substrate;

(d) computing means, in communication with said printhead and with said positioning means (c), for controlling relative positions of said printhead and the substrate, and for controlling firing of said printhead, so as to apply predetermined amounts of said radioactive fluid onto said substrate at predetermined positions;

(e) means for measuring the radioactivity that has been applied to a substrate; and

(f) computing means, receptive to data supplied by said measuring means (e) and providing feedback to said computing means (d), for controlling the amount of radioactive fluid subsequently deposited by said printhead.

4. An apparatus for depositing discrete dots of radioactive material onto a surface of a substrate, said apparatus comprising:

(a) a fluid-jet printhead;

(b) a reservoir adapted for containing and dispensing radioactive fluid, having an opening communicating with said fluid-jet printhead;

(c) means for positioning and repositioning said printhead relative to the substrate;

(d) computing means, in communication with said printhead and with said positioning means (c), for controlling relative positions of said printhead and the substrate, and for controlling firing of said printhead, so as to apply predetermined amounts of said radioactive fluid onto said substrate at predetermined positions; and

(e) coating means to apply over said substrate so as to sealingly enclose the radioactive material, a coating that is substantially transparent to the radiation of said radioactive fluid.

11. An apparatus for depositing discrete dots of radioactive material onto a surface of a substrate, sad apparatus comprising:

(a) a fluid-jet printhead;

(b) a reservoir adapted for containing and dispensing radioactive fluid, having an opening communicating with said fluid-jet printhead;

(c) means for positioning and repositioning said printhead relative to the substrate;

(d) computing means, in communication with said printhead and with said positioning means (c), for controlling relative positions of said printhead and the substrate, and for controlling firing of said printhead, so as to apply predetermined amounts of said radioactive fluid onto said substrate at predetected positions in response to a sensed amount of radioactivity.

12. The apparatus of claim 11, further comprising:

(g) curing means for curing said radiation resistant curable liquid by applying heat, irradiation or catalysis to said substrate.

13. The apparatus of claim 11, further comprising:

(h) coating means to apply over said substrate so as to sealingly enclose the radioactive material, a coating that is substantially transparent to the radiation of said radioactive fluid.

14. The apparatus of aim 11, wherein the radioactive fluid comprises:

a radioactive isotope in the form of (a) a solution of a radioactive complex, (b) a solution of a radioactive salt, (c) a radioactive isotope adsorbed onto a powder, or (d) a powder consisting essentially of radioactive and nonradioactive isotopes of an element; and

a rapidly curable radiation-resistant curable liquid.