Hardenable ceramic hydraulic cement
First Claim
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1. A method of delivering a composition which comprises:
- providing a first component comprising at least one of a calcium or sodium salt of an inorganic and/or organic acid;
providing a second component comprising sodium silicate or calcium silicate;
mixing the first and second components to form a ceramic hydraulic cement composition; and
implanting a therapeutically effective amount of the composition into an animal, wherein the first component is different from the second component, wherein the composition hardens in situ, and wherein the composition degrades in situ over a period of time to release a drug to a locally targeted area.
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Abstract
A method for delivering a therapeutically effective drug via a hardenable ceramic hydraulic cement composition including a first component of at least one sodium or calcium salts of inorganic and organic acids, a second component of at least one alkaline, and optionally third and fourth components including an organic carboxylic acid and pure water, respectively, wherein the cement composition is implanted in an animal or human body, hardens, and then degrades in situ after time to releases a amount of the drug into a locally targeted area.
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Citations
34 Claims
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1. A method of delivering a composition which comprises:
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providing a first component comprising at least one of a calcium or sodium salt of an inorganic and/or organic acid;
providing a second component comprising sodium silicate or calcium silicate;
mixing the first and second components to form a ceramic hydraulic cement composition; and
implanting a therapeutically effective amount of the composition into an animal, wherein the first component is different from the second component, wherein the composition hardens in situ, and wherein the composition degrades in situ over a period of time to release a drug to a locally targeted area. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 30, 31, 32, 33, 34)
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16. A ceramic hydraulic cement composition comprising:
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a first component comprising at least one of a calcium or sodium salt of an inorganic and/or organic acid;
a second component comprising sodium silicate or calcium silicate; and
a third component comprising an organic carboxylic acid, wherein the first component is different from the second component, and wherein the composition degrades in the presence of water in 10 hours to 4 months. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A method of delivering a composition which comprises:
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providing a first component comprising at least one of a calcium or sodium salt of an inorganic and/or organic acid;
providing a second component comprising sodium silicate or calcium silicate;
providing a third component comprising an organic carboxylic acid;
mixing the first, second, and third components to form a ceramic hydraulic cement composition; and
implanting a therapeutically effective amount of the composition into an human, wherein the first the component is different from the second component, wherein the composition hardens in situ, and wherein the composition degrades in situ over a period of time to release a drug to a locally targeted area. - View Dependent Claims (28, 29)
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Specification