Inhibitors of proteasomal activity and production for stimulating bone growth
First Claim
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1. A method to enhance bone formation in a vertebrate animal which method comprises administering to a vertebrate subject in need of such enhancement an effective amount of N-carbobenzoyl-Ile-Glu-(OtBu)-Ala-Leu-CHO (PSI).
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Abstract
Compounds that inhibit the activity of NF-κB or inhibit the activity of the proteasome or both promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation.
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6 Claims
- 1. A method to enhance bone formation in a vertebrate animal which method comprises administering to a vertebrate subject in need of such enhancement an effective amount of N-carbobenzoyl-Ile-Glu-(OtBu)-Ala-Leu-CHO (PSI).
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