Analysis of cerebral white matter for prognosis and diagnosis of neurological disorders

• US 6,463,315 B1
• Filed: 01/26/2000
• Issued: 10/08/2002
• Est. Priority Date: 01/26/2000
• Status: Expired due to Term

• Current Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Original Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Inventors: Moseley, Michael E., Klingberg, Torkel, Hedehus, Maj, Gabrieli, John D. E., Poldrack, Russell A.
• Primary Examiner(s): SHAW, SHAWNA JEANNINE
• Application Number:
  US09/491,986
• Time in Patent Office: 986 Days
• Field of Search: 600/410, 600/419, 600/544, 600/545, 324/307, 324/309, 324/306
• US Class Current: 600/410
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: G01R 33/56341 Diffusion imaging

Abstract

A method of detecting a neurological disorder such as dyslexia includes the steps of measuring microstructure of cerebral white matter, and correlating the microstructure to the presence of the neurological disorder. For dyslexia, the white matter is confined to temporo-parietal white matter. The microstructure is measured by determining cerebral white matter anisotropy using diffusion tensor magnetic resonance imaging (DTI).

Claims

1. A method of analyzing cerebral white matter in the brain of a living individual for use in evaluating a range of verbal and non-verbal cognitive processing and capacity comprising the steps of:

a) measuring microstructure of cerebral white matter in the brain using magnetic resonance diffusion tensor imaging (DTI),

b) determining neuronal fiber integrity in the cerebral white matter from the measured microstructure, and

c) correlating neuronal fiber integrity to a measure of cognitive processing of the individual to determine the possibility of developing, or the presence of, dyslexia.

2. The method as defined by claim 1 wherein step a) includes determining cerebral white matter diffusion anisotropy.

3. The method as defined by claim 2 wherein the cerebral white matter is confined to the temporo-parietal white matter.

4. The method as defined by claim 1 wherein the cerebral white matter is confined to the temporo-parietal white matter.

5. A method for use in detecting a reading disorder in an individual from cerebral-parietal white matter in the brain of the individual comprising the steps of:

a) measuring microstructure of the cerebral-parietal white matter using magnetic resonance diffusion tensor imaging (DTI), and

b) correlating the microstructure to a measure of reading ability of the individual to detect the presence of a reading disorder.

6. The method of claim 5 wherein step a) includes the use of cerebral white matter diffusion anisotropy.