Method and apparatus for magnetic resonance imaging of arteries using a magnetic resonance contrast agent

• US 6,463,318 B2
• Filed: 04/07/2001
• Issued: 10/08/2002
• Est. Priority Date: 06/07/1993
• Status: Expired due to Term

• Current Assignee: Martin R. Prince
• Original Assignee: Martin R. Prince
• Inventors: Prince, Martin R.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US09/828,429
• Publication Number:
  US 20010034483A1
• Time in Patent Office: 549 Days
• Field of Search: 600/419, 600/420, 600/431, 600/410, 324/306, 324/307, 324/309, 424/9.3, 424/9.36
• US Class Current: 600/420
• CPC Class Codes: A61B 5/201 Assessing renal or kidney functions
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61K 49/18 characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• CPC Class Codes: A61M 5/007 for contrast media
• CPC Class Codes: A61M 5/1456 with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: G01R 33/281 Means for the use of in vitro contrast agents G01R33/282 takes precedence; involving use of a contrast agent in MR imaging G01R33/5601; in vivo contrast agents A61K49/0002
• CPC Class Codes: G01R 33/5601 involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
• CPC Class Codes: G01R 33/5619 by temporal sharing of data, e.g. keyhole, block regional interpolation scheme for k-Space [BRISK]
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography
• CPC Class Codes: G01R 33/56308 Characterization of motion or flow; Dynamic imaging
• CPC Class Codes: G01R 33/5635 Angiography, e.g. contrast-enhanced angiography [CE-MRA] or time-of-flight angiography [TOF-MRA]

Abstract

The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins.

The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g., about 20-50% greater than the response of the region of interest to a series of magnetic resonance pulses before administration of a magnetic resonance contrast agent), a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention facilitates synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement. The center of k-space corresponds to the lowest spatial frequency data which dominates image contrast.

Claims

1. A method of imaging an artery of a patient using magnetic resonance imaging, the method comprising,

detecting the arrival of an administered magnetic resonance contrast agent in a region of interest;

and

performing an imaging sequence to image a portion of the artery, including collecting image data which is representative of a substantial portion of a center of k-space after detecting the arrival of the administered magnetic resonance contrast agent in the region of interest.

2. The method of claim 1 wherein collecting image data which is representative of a substantial portion of the center of k-space includes collecting the image data which is representative of a substantial portion of the center of k-space substantially at the beginning of the imaging sequence.

3. The method of claim 2 wherein the imaging sequence is a 3D imaging sequence.

4. The method of claim 1 further including continuously or periodically monitoring the region of interest to detect the arrival of the contrast agent in the region of interest.

5. The method of claim 1 wherein collecting image data which is representative of a substantial portion of the center of k-space includes collecting image data which is representative of a substantial portion of the center of k-space in response to detecting the arrival of the contrast agent in the region of interest.

6. The method of claim 1 wherein the image data which is representative of a substantial portion of the center of k-space is collected during the arterial phase of contrast enhancement in the portion of the artery and wherein a substantial portion of the periphery of k-space is collected after collecting image data which is representative of the substantial portion of the center of k-space.

7. The method of claim 6 further including instructing the patient to hold his breath before collecting image data which is representative of the substantial portion of the center of k-space.

8. The method of claim 1 wherein a substantial portion of the periphery of k-space is collected before collecting image data which is representative of the substantial portion of the center of k-space and wherein the image data which is representative of the substantial portion of the center of k-space is collected during the arterial phase of contrast enhancement in the portion of the artery.

9. A method of imaging an artery of a patient using magnetic resonance imaging, the method comprising,

administering a magnetic resonance contrast agent;

detecting a predetermined concentration of the magnetic resonance contrast agent in a region of interest; and

imaging at least a portion of the artery including collecting image data which is representative of at least a portion of a center of k-space after detecting the predetermined concentration of the contrast agent in the region of interest and while the concentration of the contrast agent in the artery is higher than a concentration of the contrast agent in veins adjacent to the artery.

10. The method of claim 9 further including detecting an arrival of the magnetic resonance contrast agent in the region of interest.

11. The method of claim 10 wherein imaging at least a portion of the artery includes collecting image data of a 3D imaging sequence and wherein collecting image data which is representative of at least a portion of the center of k-space includes collecting the image data substantially at a beginning of the 3D imaging sequence.

12. The method of claim 10 wherein collecting image data which is representative of at least a portion of a center of k-space further includes collecting image data which is representative of at least a portion of the center of k-space in response to detecting the arrival of the magnetic resonance contrast agent in the region of interest.

13. The method of claim 12 wherein imaging at least a portion of the artery includes collecting image data of a 3D imaging sequence and wherein collecting image data which is representative of at least a portion of the center of k-space includes collecting the image data substantially at a beginning of the 3D imaging sequence.

14. The method of claim 12 wherein administering a magnetic resonance contrast agent includes administering the magnetic resonance contrast agent to the patient in a bolus type injection.

15. The method of claim 14 wherein imaging at least a portion of the artery includes collecting image data of a 3D imaging sequence and wherein collecting image data which is representative of at least a portion of the center of k-space includes collecting the image data substantially at a beginning of the 3D imaging sequence.

16. The method of claim 9 wherein the region of interest includes at least the portion of the artery and the artery is the aorta.

17. The method of claim 9 wherein imaging at least a portion of the artery further includes collecting image data which is representative of at least a portion of a periphery of k-space after collecting image data which is representative of at least a portion of the center of k-space.

18. A method of imaging an artery of a patient using magnetic resonance imaging, the method comprising,

monitoring a region of interest to detect the arrival of an administered magnetic resonance contrast agent in the region of interest;

initiating a 3D imaging sequence after detecting the arrival of the administering magnetic resonance contrast agent in the region of interest; and

collecting image data which is representative of a central portion of k-space substantially at the beginning of the 3D imaging sequence.

19. The method of claim 18 wherein initiating the 3D imaging sequence includes initiating the 3D imaging sequence in response to visually detecting the arrival of the administered magnetic resonance contrast agent in the region of interest.

20. The method of claim 18 wherein the image data which is representative of the central portion of k-space is collected during the arterial phase of contrast enhancement in the artery and wherein a peripheral portion of k-space is collected after collecting the image data which is representative of the central portion of k-space.

21. The method of claim 20 further including instructing the patient to hold his breath before collecting image data which is representative of the central portion of k-space.

22. The method of claim 18 wherein monitoring the region of interest to detect the arrival of the administered magnetic resonance contrast agent includes periodically measuring the response of the region of interest to magnetic resonance pulses to detect the arrival of the administering magnetic resonance contrast agent in the region of interest.

23. The method of claim 18 wherein a peripheral portion of k-space is collected after collecting the central portion of k-space and wherein monitoring the region of interest to detect the arrival of an administering magnetic resonance contrast agent in the region of interest further includes visually displaying the region of interest to detect the onset of arterial phase of contrast enhancement in the artery.

24. The method of claim 18 wherein monitoring the region of interest to detect the arrival of an administering magnetic resonance contrast agent in the region of interest further includes monitoring the region of interest to detect the arrival of the administering magnetic resonance contrast agent in the artery.