Rate adaptive cardiac rhythm management device using transthoracic impedance
First Claim
1. A method of determining transthoracic impedance in a cardiac rhythm management device, the method comprising:
- repeatedly delivering a multiple phase stimulus having more than two phases to a thorax region of a patient; and
demodulating more than one phase of a response to the multiple phase stimulus to obtain sample points of a response signal including transthoracic impedance information, wherein the demodulating includes sampling a response to more than one phase of the multiple phase stimulus and combining the sampled responses.
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Abstract
A cardiac rhythm management (CRM) device detects transthoracic impedance, extracts ventilation or other information, and adjusts a delivery rate of the CRM therapy accordingly. A four-phase sequence of alternating direction current pulse stimuli is periodically delivered to a patient'"'"'s thorax. A transthoracic impedance signal is extracted using a weighted demodulation. Signal processing extracts ventilation information and removes cardiac stroke information using an adaptive lowpass filter. The adaptive filter cutoff frequency is based on the patient'"'"'s heart rate; a higher cutoff frequency is provided for higher heart rates. Peak/valley detection indicates tidal volume, which is integrated to extract minute ventilation (MV). Short and long term averages are formed and compared to establish a MV indicated rate. Rate adjustment ignores MV information when a noise-measurement exceeds a threshold. An interference avoidance circuit delays delivery of the stimuli when telemetry pulses or other interfering signals are detected.
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Citations
25 Claims
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1. A method of determining transthoracic impedance in a cardiac rhythm management device, the method comprising:
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repeatedly delivering a multiple phase stimulus having more than two phases to a thorax region of a patient; and
demodulating more than one phase of a response to the multiple phase stimulus to obtain sample points of a response signal including transthoracic impedance information, wherein the demodulating includes sampling a response to more than one phase of the multiple phase stimulus and combining the sampled responses. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
demodulating a noise-response signal in the absence of the stimuli;
comparing the noise-response signal to a threshold value to determine whether the noise-response signal exceeds the threshold value; and
wherein the step of adjusting a rate of delivering cardiac rhythm management therapy includes delivering the cardiac rhythm management therapy independent of the ventilation information when the noise-response signal exceeds the threshold value.
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8. The method of claim 1, in which repeatedly delivering a multiple phase stimulus having more than two phases includes repeatedly delivering a multiple phase stimulus having alternating polarity phases.
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9. The method of claim 8, in which delivering a multiple phase stimulus having more than two phases includes repeatedly delivering a multiple phase stimulus having alternating direction current pulse phases.
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10. The method of claim 1, in which repeatedly delivering a multiple phase stimulus having more than two phases includes repeatedly delivering a square wave stimulus.
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11. The method of claim 1, in which repeatedly delivering a multiple phase stimulus having more than two phases includes repeatedly delivering a square wave including four alternating direction current pulses having an amplitude magnitude that is less than a tissue stimulation threshold.
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12. The method of claim 11, in which the amplitude magnitude is less than approximately 1 milliampere.
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13. The method of claim 12, in which the amplitude magnitude is approximately 320 microamperes.
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14. The method of claim 1, in which the duration of each phase of the multiple phase stimulus is approximately between 1 and 100 microseconds.
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15. The method of claim 14, in which the duration of each phase of the multiple phase stimulus is approximately 20 microseconds.
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16. The method of claim 1, in which repeatedly delivering a multiple phase stimulus having more than two phases includes waiting for a time period between successive deliveries of the multiple phase stimulus.
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17. The method of claim 16, in which the time period is less than approximately 55 milliseconds.
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18. The method of claim 1, further comprising:
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detecting an interference signal; and
delaying delivery of the multiple phase stimulus having more than two phases when the interference signal is detected.
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19. The method of claim 18, in which detecting an interference signal includes detecting a telemetry signal, and delaying delivery of the multiple phase stimulus having more than two phases when the interference signal is detected includes delaying delivery of the multiple phase stimulus when the telemetry signal is detected.
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20. A method of determining transthoracic impedance in a cardiac rhythm management device, the method comprising:
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repeatedly delivering a multiple phase stimulus having more than two consecutive phases of alternating polarity and substantially similar duration and amplitude magnitude to a thorax region of a patient; and
demodulating more than one phase of the multiple phase stimuli to obtain sample points of a response signal including transthoracic impedance information. - View Dependent Claims (21, 22, 23, 24, 25)
demodulating a noise-response signal in the absence of the stimuli;
comparing the noise-response signal to a threshold value to determine whether the noise-response signal exceeds the threshold value; and
wherein the step of adjusting a rate of delivering cardiac rhythm management therapy includes delivering the cardiac rhythm management therapy independent of the ventilation information when the noise-response signal exceeds the threshold value.
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23. The method of claim 22, in which detecting an interference signal includes detecting a telemetry signal, and delaying delivery of the multiple phase stimulus having more than two phases when the interference signal is detected includes delaying delivery of the multiple phase stimulus when the telemetry signal is detected.
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24. The method of claim 20, in which repeatedly delivering a multiple phase stimulus having more than two phases includes repeatedly delivering a square wave including four alternating direction current pulses.
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25. The method of claim 20, in which repeatedly delivering a multiple phase stimulus having more than two phases includes strobing the multiple phase stimulus.
Specification