Method for facilitating absorption of pharmaceutically active compounds
First Claim
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1. A method for facilitating the absorption of a pharmaceutical through human skin comprising the steps of:
- administering said pharmaceutical through a portion of said skin, and placing an exothermic heating means proximate said portion of skin to increase the temperature on and around said portion of skin by heating to within a safe, pre-designed narrow temperature range for a safe, pre-designed length of time, said exothermic heating means comprising a pre-determined amount of iron powder and water disposed in a chamber.
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Abstract
Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.
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Citations
74 Claims
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1. A method for facilitating the absorption of a pharmaceutical through human skin comprising the steps of:
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administering said pharmaceutical through a portion of said skin, and placing an exothermic heating means proximate said portion of skin to increase the temperature on and around said portion of skin by heating to within a safe, pre-designed narrow temperature range for a safe, pre-designed length of time, said exothermic heating means comprising a pre-determined amount of iron powder and water disposed in a chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55)
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56. An apparatus for facilitating the absorption of pharmaceuticals through human skin comprising the steps of:
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a chamber comprising air-impermeable walls and having pre-determined number of holes with pre-determined size in at least one wall to allow the passage of air into said chamber;
determined amount of a heat generating medium comprising iron powder and water disposed in said chamber said amount of said heat generating medium being so selected that the heat generation by said heat generating medium in said chamber lasts a pre-determined length of time. - View Dependent Claims (57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70)
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71. A method for making a heat generating apparatus comprising:
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selecting pre-determined amounts of iron powder, activated carbon and water, mixing iron powder and activated carbon with a liquid in such a ratio that the mixture is semi-solid, placing said mixture into a chamber with air impermeable walls, said chamber having at least one opening, evaporating said liquid to form an intermediate mixture, adding pre-determined amounts of water into said intermediate mixture, to form an exothermic heat generating medium that generates heat at a safe, pre-designed temperature for a safe, pre-designed length of time and covering said at least one opening with a cover having a desired air permeability. - View Dependent Claims (72)
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73. The method of making a heat generating apparatus comprising:
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mixing iron powder and an amount of water together, said amount of water being sufficient to prevent a heat generating reaction, placing said mixture into a chamber having an air impermeable wall and at least one opening, evaporating a portion of said amount of water until a pre-determined amount of water is left in said mixture, covering said at least one opening with a cover having a safe, pre-designed air permeability. - View Dependent Claims (74)
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Specification