pH-dependent sustained release, drug-delivery composition
First Claim
1. A pH-dependent sustained release, drug delivery composition, wherein the release is controlled by a diffusion barrier formed by the interaction of a pH-dependent gelling material and a pH-independent non-gelling material, comprising a polymer matrix, by weight, (a) 10 to 50% sodium alginate, (b) 2 to 15% propylene glycol alginate and (c) 40 to 80% of a pharmaceutical medicament, which will achieve less than 40% dissolution of the medicament within 2 hours at an acidic pH, and dissolution of the remaining drug at neutral or alkaline pH over a period of at least 10 hours.
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Accused Products
Abstract
A pH-dependent sustained release, drug delivery composition capable of being formed into tablets or pellets, wherein the release is controlled by a diffusion barrier formed by the interaction of a pH-dependent gelling material and a pH-independent non-gelling material, comprising a polymer matrix comprising, by weight, (a) 10 to 50% sodium alginate, (b) 2 to 15% propylene glycol alginate and (c) 40 to 80% of a pharmaceutical medicament.
68 Citations
9 Claims
- 1. A pH-dependent sustained release, drug delivery composition, wherein the release is controlled by a diffusion barrier formed by the interaction of a pH-dependent gelling material and a pH-independent non-gelling material, comprising a polymer matrix, by weight, (a) 10 to 50% sodium alginate, (b) 2 to 15% propylene glycol alginate and (c) 40 to 80% of a pharmaceutical medicament, which will achieve less than 40% dissolution of the medicament within 2 hours at an acidic pH, and dissolution of the remaining drug at neutral or alkaline pH over a period of at least 10 hours.
Specification
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- Resources
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Current AssigneeFMC Corporation
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Original AssigneeISP Investments, Inc. (Ashland Global Holdings, Inc.)
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InventorsDrefko, William, Moroni, Antonio
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Primary Examiner(s)Page, Thurman K.
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Assistant Examiner(s)FUBARA, BLESSING M
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Application NumberUS09/814,084Publication NumberTime in Patent Office573 DaysField of Search424/486, 424/489, 424/452, 424/455, 424/465US Class Current424/486CPC Class CodesA61K 9/205 Polysaccharides, e.g. algin...
