Hydrophilic somatostatin analogs
First Claim
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1. A compound comprising a somatostatin analog of the formula:
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Abstract
The invention features novel somatostatin analogs that may be readily labeled with toxic or non-toxic detectable labels. These unlabeled and labeled analogs are useful for specifically targeting somatostatin receptor bearing cells, in particular neoplastic cells. Labeled analogs are useful, for example, for tumor localization and detection. Where labeled with a toxic label (e.g., radioactivity), the analogs are useful for the targeted delivery of toxicity to somatostatin receptor-bearing cells, in particular neoplastic cells.
Also disclosed are methods for treating and detecting neoplasms, and methods for imaging somatostatin receptor-bearing cells.
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20 Claims
- 1. A compound comprising a somatostatin analog of the formula:
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