Photoacoustic material analysis

• US 6,466,806 B1
• Filed: 05/17/2000
• Issued: 10/15/2002
• Est. Priority Date: 05/17/2000
• Status: Expired due to Term

• Current Assignee: LifeWatch Technologies Ltd. (Koninklijke Philips N.V.)
• Original Assignee: Card Guard Scientific Survival Limited (Koninklijke Philips N.V.)
• Inventors: Trachtenberg, Leonid, Kravetz, Anatoly, Geva, Jacob
• Primary Examiner(s): Winakur, Eric F.
• Assistant Examiner(s): KREMER, MATTHEW J
• Application Number:
  US09/573,528
• Time in Patent Office: 881 Days
• Field of Search: 600/309-310, 600/322-324, 600/316, 600/336, 600/473, 600/476, 374/45, 356/39-42
• US Class Current: 600/310
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: G01N 21/1702 with opto-acoustic detection, e.g. for gases or analysing solids

Abstract

Disclosed is a method and apparatus for determining the concentration of an interest component in a medium by resonant photoacoustic spectroscopy (RPAS) with a light pulse-train comprising equidistant short pulses having variable duration, frequency, number, and power. The light wavelength is selected so as to be absorbed by the component of interest. Upon irradiation, acoustic oscillations are generated by the absorbed light in a relatively thin layer of the medium, characterized by a heat-diffusing length. The frequency repetition of the light short pulses in the pulse-train is chosen equal to the natural acoustic oscillation frequency of the thin layer of the medium that can be considered as a thin membrane. So, the acoustic oscillation becomes resonant. Measuring of the amplitude and the frequency of the resonant oscillations determine the concentration of interest component. The method and apparatus are suitable monitoring of blood components, especially glucose.

Claims

1. Apparatus for determination of an interest component in a human body, comprising:

at least one light source operative to emit a light pulse-train comprising equidistant short pulses with variable in the frequency, duration, number and power output to excite resonant acoustic oscillations in said human body;

a detector for detecting said resonant acoustic oscillations and generating an electrical signal representative of the amplitude and resonant frequency of said resonant acoustic oscillations; and

a processor for determining the concentration of said component in response to said electrical signal.

2. Apparatus according to claim 1 wherein said light source is operable to emit said short light pulses with a predetermined wavelength for exciting of said resonant acoustic oscillation in said human body due to absorption of light by said component and subsequent adiabatic temperature rise in a testing area of said human body.

3. Apparatus according to claim 1 wherein said light source is a pulsed laser.

4. Apparatus according to claim 1 wherein said light source is a neodymium containing medium laser.

5. Apparatus according to claim 1 wherein said light source is an Erbium-doped fiber laser for noninvasive blood glucose monitoring.

6. Apparatus according to claim 1 wherein said light source is an Er-glass rod or slab laser with pumping by diode lasers or flash lamp.

7. Apparatus according to claim 1 wherein said light source is a tunable Co:

MaF₂ laser.

8. Apparatus according to claim 1 and further comprising a Q-switch located within an optical resonator of said light source.

9. Apparatus according to claim 8 wherein said Q-switch is a LiF crystal with color centers.

10. Apparatus according to either of claim 8 or claim 9 wherein said Q-switch provides pulse-train generation giving equidistant short pulses having variable duration, frequency, number and power.

11. Apparatus according to claim 1 and further comprising an optical converter for converting the wavelength of said light source.

12. Apparatus according to claim 1 wherein said light source is a tunable diode laser.

13. Apparatus according to claim 12 further comprising an optical fiber amplifier to increase the output capabilities of the laser.

14. Apparatus according to claim 1 wherein said light source is a fiber coupled diode laser array.

15. Apparatus according to claim 1 wherein said detector of said resonant acoustic oscillations is a microphone.

16. Apparatus according to claim 1 further comprising a measuring acoustic cell adapted to enclose to surface of said human body such that light from said light source reaches said surface within the area enclosed by said cell.

17. Apparatus according to claim 16 wherein said measuring acoustic cell is suitable for detecting said resonant acoustic oscillations.

18. Apparatus according to claim 1 wherein said detector of said resonant acoustic oscillations is a piezoelectric crystal.

19. Apparatus according to claim 1 wherein said detector of said resonant acoustic oscillations is an optical fiber sensor.

20. Apparatus according to claim 1 wherein said detector of said resonant acoustic oscillations is a laser interferometer.

21. A method of determining a concentration of an interest component in a human body comprising the steps of:

irradiating a surface of said human body having said interest component with a light pulse-train comprising equidistant short pulses having variable duration, frequency, number, and power sufficient to excite resonant acoustic oscillations in said human body;

detecting said resonant/acoustic oscillations;

generating as electrical signal representative of the amplitude and the resonant frequency said resonant acoustic oscillations; and

determining the concentration of said interest component in said human body in response to said electrical signal.

22. A method according to claim 21 wherein said irradiating step comprises a light beam having a predetermined wavelength for exciting of said resonant acoustic, oscillations in said human body due to absorption of light by said interest component and subsequent adiabatic temperature rise in a testing area of said human body.

23. A method according to claim 21 and further comprising tuning said wavelength to an absorption band of said, interest component sufficient to excite resonant acoustic-oscillations in said human body.