Method and apparatus for mixing liquid samples in a container using rotating magnetic fields

• US 6,467,946 B1
• Filed: 04/24/2001
• Issued: 10/22/2002
• Est. Priority Date: 04/24/2001
• Status: Expired due to Fees

• Current Assignee: Siemens Healthcare Diagnostics Incorporated (Siemens AG)
• Original Assignee: Dade Microscan, Inc.
• Inventors: Gebrian, Peter Louis
• Primary Examiner(s): Cooley, Charles E.
• Application Number:
  US09/841,468
• Publication Number:
  US 20020154570A1
• Time in Patent Office: 546 Days
• Field of Search: 366/208, 366/209, 366/212, 366/218, 366/219, 366/273, 366/274, 416/3, 417/420, 464/29, 435/302.1, 266/234
• US Class Current: 366/273
• CPC Class Codes: B01F 2101/23 Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
• CPC Class Codes: B01F 27/116 Stirrers shaped as cylinders, balls or rollers
• CPC Class Codes: B01F 33/452 using independent floating stirring elements

Abstract

Mixing a liquid solution in a container by rotating a pair of bar-shaped magnets in a coordinated pattern in which lines parallel to the axes of the bar-shaped magnets remain normal to one another, the magnets disposed in close proximity to and on opposite sides of the container a distance above the bottom of the container so that a magnetic mixing member is caused to rotate in the liquid about the same distance above the bottom of the container. Relative vertical movement of the magnets and the container generates a vortex-like mixing action throughout the container.

Claims

1. A method for mixing a liquid solution contained in a container having a false bottom, the method comprising:

placing a ferromagnetic mixing member within the liquid solution contained in the container; and

,

rotating a pair of magnetic fields in a circular pattern in close proximity to the container near the location of the false bottom,

wherein rotating the pair of magnetic fields comprises rotating a pair of magnets in a coordinated pattern in which lines parallel to the axes of the magnets remain normal to one another,

so that magnetic forces acting upon the mixing member cause it to revolve thereby generating a mixing motion within the liquid solution.

2. The method of claim 1 wherein the pair of magnetic fields are rotated in close proximity to opposite sides of the container.

3. The method of claim 1 wherein the magnets comprises bar-shaped permanent or semi-permanent magnets.

4. The method of claim 1 wherein rotating the magnetic fields comprises rotating a pair of disks containing said magnets in a coordinated pattern in which the magnetic fields of the two separate magnets are 90 degrees out of phase with one another.

5. The method of claim 1 wherein the mixing member is spherical.

6. The method of claim 1 wherein the mixing member is made of an iron alloy and has a diameter in the range 2-6 mm.

7. The method of claim 1 wherein the mixing member has a protective coating to prevent contamination having thickness about 25 microns.

8. The method of claim 7 wherein the protective coating comprises a material selected from the group consisting of parylene, SURLYN™

and TEFLON™

plastics.

9. The method of claim 1 wherein the liquid container is supported within a rack and the rack is moved through the rotating magnetic fields.

10. A method for mixing a liquid solution contained in a container, the method comprising:

placing a ferromagnetic mixing member within the liquid solution contained in the container;

rotating a pair of magnetic fields in a circular pattern in close proximity to the container; and

,

moving the container vertically relative to the magnetic fields so that magnetic forces acting upon the mixing member cause it to revolve thereby generating a mixing motion throughout the entirety of the liquid solution.

11. The method of claim 10 for mixing a liquid solution contained in a container wherein rotating the pair of magnetic fields comprises rotating a pair of bar-shaped magnets in a coordinated pattern in which lines parallel to the axes of the bar-shaped magnets remain normal to one another.

12. The method of claim 10 wherein the magnetic fields are rotated in close proximity to opposite sides of the container.

13. The method of claim 10 wherein the ferromagnetic mixing member is spherical.

14. An apparatus for mixing a liquid solution within a liquid container, the apparatus comprising:

a liquid container having a false bottom;

a spherical ferromagnetic mixing member within the liquid in the container;

a pair of magnetic field sources positioned at opposite sides of the container proximate the false bottom; and

,

means for rotating the magnetic field sources in circular patterns in close proximity to the liquid container,

wherein the means for rotating the magnetic field sources comprise rotating a pair of bar-shaped magnets in a coordinated pattern in which lines parallel to the axes of the bar-shaped magnets remain normal to one another,

so that magnetic forces acting upon the magnetic mixing member cause it to rotate, thereby generating a mixing motion within the liquid solution.

15. The apparatus of claim 14 wherein the magnetic field sources are rotated in close proximity to the sides of the liquid container.

16. The apparatus of claim 14 for mixing a liquid sample solution within a liquid container wherein rotating the magnetic field sources comprises rotating a motor shaft having said magnetic field sources attached thereto.