Technique to monitor drug delivery noninvasively in vivo
First Claim
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1. A composition for NMR imaging during drug delivery, comprising:
- a) a paramagnetic chelate with a paramagnetic ion and in amount sufficient to enhance NMR imaging, b) a liposome comprising a bilayer and an interior volume and in an amount sufficient to permit delivery of said liposome to a tissue, wherein said liposome carries said paramagnetic chelate, c) a polyalkylether associated with said liposome, and d) a therapeutic agent in a therapeutic amount, wherein liposome carries said therapeutic agent.
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Abstract
The present invention relates to the field of diagnostic imaging and more specifically to the field of monitoring drug delivery using non-invasive imaging techniques. The present invention provides for imaging agents and compositions useful for NMR, computed tomography, scintigraphy, PET and any other type of imaging where the imaging agent can be carried by liposomes or other lipid based vehicles, such as micelles or suspended lipid aggregates.
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Citations
21 Claims
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1. A composition for NMR imaging during drug delivery, comprising:
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a) a paramagnetic chelate with a paramagnetic ion and in amount sufficient to enhance NMR imaging, b) a liposome comprising a bilayer and an interior volume and in an amount sufficient to permit delivery of said liposome to a tissue, wherein said liposome carries said paramagnetic chelate, c) a polyalkylether associated with said liposome, and d) a therapeutic agent in a therapeutic amount, wherein liposome carries said therapeutic agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of drug delivery in a mammal, comprising:
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a) administering to a mammal in need thereof a composition, comprising;
i) a paramagnetic chelate with a paramagnetic ion and in amount sufficient to enhance NMR imaging, ii) a liposome comprising a bilayer and an interior volume and in an amount sufficient to permit delivery of said liposome to a tissue, wherein said liposome carries said paramagnetic chelate, iii) a polyalkylether associated with said liposome, and iv) a therapeutic agent in a therapeutic amount, wherein said liposome carries said therapeutic agent, whereby drug delivery is achieved. - View Dependent Claims (14, 15, 16, 17)
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18. A method of monitoring drug delivery in a mammal, comprising:
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a) administering to a mammal need thereof a composition, comprising;
i) an imaging agent and in amount sufficient to enhance NMR imaging, ii) a liposome comprising a bilayer and an interior volume and in an amount sufficient to permit delivery of said liposome to a tissue, wherein said liposome carries said imaging agent and said liposome enhances imaging compared to the absence of said imaging agent and said liposome selectively distributes said imaging agent to a tumor tissue compared to a non-tumor tissue, iii) a polyalkylether associated with said liposome, and iv) a therapeutic agent in an therapeutic amount, wherein said liposome carries said therapeutic agent, and b) imaging a tissue of said mammal, wherein drug delivery can be monitored. - View Dependent Claims (19, 20, 21)
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Specification